Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08NS001240-04
Application #
3084065
Study Section
Neurological Disorders Program Project Review A Committee (NSPA)
Project Start
1987-07-01
Project End
1992-06-30
Budget Start
1990-07-01
Budget End
1991-06-30
Support Year
4
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Kowall, N W; McKee, A C; Yankner, B A et al. (1992) In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment. Neurobiol Aging 13:537-42
Chen, M; Tempst, P; Yankner, B A (1992) Secretogranin I/chromogranin B is a heparin-binding adhesive protein. J Neurochem 58:1691-8
Busciglio, J; Lorenzo, A; Yankner, B A (1992) Methodological variables in the assessment of beta amyloid neurotoxicity. Neurobiol Aging 13:609-12
Kowall, N W; Beal, M F; Busciglio, J et al. (1991) An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P. Proc Natl Acad Sci U S A 88:7247-51
Yankner, B A; Mesulam, M M (1991) Seminars in medicine of the Beth Israel Hospital, Boston. beta-Amyloid and the pathogenesis of Alzheimer's disease. N Engl J Med 325:1849-57
Chen, M; Yankner, B A (1991) An antibody to beta amyloid and the amyloid precursor protein inhibits cell-substratum adhesion in many mammalian cell types. Neurosci Lett 125:223-6
Yankner, B A; Caceres, A; Duffy, L K (1990) Nerve growth factor potentiates the neurotoxicity of beta amyloid. Proc Natl Acad Sci U S A 87:9020-3
Yankner, B A; Benowitz, L I; Villa-Komaroff, L et al. (1990) Transfection of PC12 cells with the human GAP-43 gene: effects on neurite outgrowth and regeneration. Brain Res Mol Brain Res 7:39-44
Yankner, B A; Duffy, L K; Kirschner, D A (1990) Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science 250:279-82
Yankner, B A; Dawes, L R; Fisher, S et al. (1989) Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 245:417-20