The overall goal of this research proposal is to develop and validate proton magnetic resonance (MR) imaging techniques that can identify the neuropathologic bases of cerebral white matter abnormalities in the elderly. The applicant proposes to validate specific correspondences between histopathologic and MR phenomena and between clinical symptomatology and MR. The proposal has two components: 1) postmortem MR imaging of brains from patients with clinical diagnoses of Alzheimer's disease, patients with dementia due to infarction or to Binswanger's disease, and nondemented patients with and without cerebrovascular disease; and 2) antemortem MR imaging in patients with and without dementia, and in patients with and without risk factors for cerebrovascular disease. The relation of MR white matter abnormality to the presence and severity of clinical syndromes such as dementia, arterial hypertension, and labile arterial pressure, as formulated with these investigations, will guide the applicant in the development of novel MR imaging techniques, including diffusion and perfusion imaging.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08NS001325-04
Application #
3084251
Study Section
Neurological Disorders Program Project Review A Committee (NSPA)
Project Start
1988-09-01
Project End
1993-08-31
Budget Start
1991-09-01
Budget End
1992-08-31
Support Year
4
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199