Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08NS001672-04
Application #
2036406
Study Section
NST-2 Subcommittee (NST)
Project Start
1993-09-01
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Southern California
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Simard, Marie; Arcuino, Gregory; Takano, Takahiro et al. (2003) Signaling at the gliovascular interface. J Neurosci 23:9254-62
Zhang, Wei; Nwagwu, Chiedozie; Le, Duc Minh et al. (2003) Increased invasive capacity of connexin43-overexpressing malignant glioma cells. J Neurosurg 99:1039-46
Simard, Marie; Zhang, Wei; Hinton, David R et al. (2002) Tamoxifen-induced growth arrest and apoptosis in pituitary tumor cells in vitro via a protein kinase C-independent pathway. Cancer Lett 185:131-8
Spiller, M; Tenner, M S; Couldwell, W T (2001) Effect of absorbable topical hemostatic agents on the relaxation time of blood: an in vitro study with implications for postoperative magnetic resonance imaging. J Neurosurg 95:687-93
Zhang, W; Couldwell, W T; Song, H et al. (2000) Tamoxifen-induced enhancement of calcium signaling in glioma and MCF-7 breast cancer cells. Cancer Res 60:5395-400
Zhang, W; Couldwell, W T; Simard, M F et al. (1999) Direct gap junction communication between malignant glioma cells and astrocytes. Cancer Res 59:1994-2003
Zhang, W; Law, R E; Hinton, D R et al. (1997) Inhibition of human malignant glioma cell motility and invasion in vitro by hypericin, a potent protein kinase C inhibitor. Cancer Lett 120:31-8
Couldwell, W T; Law, R E; Hinton, D R et al. (1996) Protein kinase C and growth regulation of pituitary adenomas. Acta Neurochir Suppl 65:22-6
Zhang, W; Hinton, D R; Surnock, A A et al. (1996) Malignant glioma sensitivity to radiotherapy, high-dose tamoxifen, and hypericin: corroborating clinical response in vitro: case report. Neurosurgery 38:587-90;discussion 590-1
Couldwell, W T; Hinton, D R; Surnock, A A et al. (1996) Treatment of recurrent malignant gliomas with chronic oral high-dose tamoxifen. Clin Cancer Res 2:619-22

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