Treatment of cerebral ischemia now stands on the frontier of a new era where emphasis will be placed on clinical outcomes. It is important to use the best clinical and technological information available to develop outcome based predictors for patients with ischemic stroke. It is also important to continue to explore how improvements in technology may enhance our ability to predict and influence clinical outcomes. The projects are designed to predict stroke outcome: 1) Data from a population-based study of ischemic stroke patients less than 45 years of age will be analyzed. The contribution of cerebral angiography in determining stroke etiology and complication rate of cerebral angiography will be described; 2) The recurrence of ischemic stroke and other thromboembolic events will be determined in a group of ischemic stroke patients with normal or abnormal echocardiograms. The rate of recurrence of embolic events in patients with and without atrial septal aneurysm, aortic arch atheroma, intracardiac thrombus and other abnormalities will be compared; 3) The NINDS Stroke Data Bank will be analyzed to develop a multivariable predictor of 30 day and l year survival and stroke recurrence for patients with cerebral infarction. These predictors will be validated using data to be collected from the ongoing Maryland Stroke Data Bank (MSDB); and 4) Long term followup data which is available for patients enrolled at the University of Maryland Medical Center in the Pilot, NINDS and MSDB from 1980 to l989 will be analyzed. This database of over a 1000 patients will be used to test and refine a previously published predictor on the risk of stroke recurrence at 2 years. New predictors of death and stroke recurrence at 2, 5 and 10 years will be developed. These projects will improve the ability to predict stroke outcomes and will explore the contribution of new technologies to stroke diagnosis and outcome.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Clinical Investigator Award (CIA) (K08)
Project #
1K08NS001764-01A1
Application #
2259926
Study Section
NST-2 Subcommittee (NST)
Project Start
1995-06-01
Project End
2000-05-31
Budget Start
1995-06-01
Budget End
1996-05-31
Support Year
1
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Neurology
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201
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Wozniak, M A; Kittner, S J; Price, T R et al. (1999) Stroke location is not associated with return to work after first ischemic stroke. Stroke 30:2568-73
Giles, W H; Kittner, S J; Croft, J B et al. (1999) Distribution and correlates of elevated total homocyst(e)ine: the Stroke Prevention in Young Women Study. Ann Epidemiol 9:307-13
Kittner, S J; Stern, B J; Wozniak, M et al. (1998) Cerebral infarction in young adults: the Baltimore-Washington Cooperative Young Stroke Study. Neurology 50:890-4
Earley, C J; Kittner, S J; Feeser, B R et al. (1998) Stroke in children and sickle-cell disease: Baltimore-Washington Cooperative Young Stroke Study. Neurology 51:169-76
Sloan, M A; Kittner, S J; Feeser, B R et al. (1998) Illicit drug-associated ischemic stroke in the Baltimore-Washington Young Stroke Study. Neurology 50:1688-93
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Rohr, J; Kittner, S; Feeser, B et al. (1996) Traditional risk factors and ischemic stroke in young adults: the Baltimore-Washington Cooperative Young Stroke Study. Arch Neurol 53:603-7