This application for a Physician Scientist Award is intended to enable the candidate to become an independent researcher in neurobiology, with expertise in molecular genetic approaches and a focus on problems of particular relevance to aging, such as Alzheimer's disease. Phase I will include a program of independent reading designed by the sponsor, Dr. David Patterson, auditing courses at the University of Colorado Health Sciences Center, and attending seminars there and at the Eleanor Roosevelt Institute, and will involve the candidate in laboratory projects currently underway in Dr. Patterson's laboratory in order to learn the techniques of molecular genetics. These projects include development of a somatic cell hybrid model for examination of the expression of the amyloid precursor protein gene and the function of the various forms of the protein it encodes, isolation and identification of the proteins bound by the serine protease inhibitor domain of the amyloid precursor protein, and more exact definition of the genetic material required for phenotypic Down's syndrome. In Phase II the candidate will continue work on Alzheimer disease and will begin an examination of the molecular genetics of amyotrophic lateral sclerosis. The candidate's ultimate goal is an academic career in neurology, with research on neurodegenerative diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Physician Scientist Award (K11)
Project #
5K11AG000452-03
Application #
3084941
Study Section
Aging Review Committee (AGE)
Project Start
1990-01-01
Project End
1994-12-31
Budget Start
1992-01-01
Budget End
1992-12-31
Support Year
3
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Graw, S L; Gardiner, K; Hall-Johnson, K et al. (1995) Molecular analysis and breakpoint definition of a set of human chromosome 21 somatic cell hybrids. Somat Cell Mol Genet 21:415-28
Patterson, D; Rahmani, Z; Donaldson, D et al. (1993) Physical mapping of chromosome 21. Prog Clin Biol Res 384:33-50
Donaldson, D H; Britt, D E; Jones, C et al. (1993) Localization of the gene for the ciliary neurotrophic factor receptor (CNTFR) to human chromosome 9. Genomics 17:782-4