Although the incidence of AIDS-associated non-Hodgkin's lymphoma (AIDS- NHL) continues to increase as the AIDS epidemic progresses, the incidence of T-cell associated AIDS-NHL has only sporadically been reported. At San Francisco General Hospital, an increase in T-cell AIDS-NHL has recently been seen, and in preliminary studies, we found HIV clonally integrated into the DNA of three out of four CD4-expressing monoclonal T-cell AIDS- NHL analyzed. In two cases analyzed in depth, HIV was found integrated with the fur gene, located immediately 5' to the c-fes/fps protooncogene. As a part of Phases I and II of this proposal, the project will focus on analyzing the HIV's involved in T-cell AIDS-NHL to determine whether: a) mutant HIV's capable of causing rapid cellular transformation have evolved; c-fes/fps expression is modulated by HIV in the first two cases analyzed and determine the HIV genes critical for inducing the transformed phenotype in association with c-fes/fps.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Physician Scientist Award (K11)
Project #
5K11AI001163-04
Application #
2457624
Study Section
Special Emphasis Panel (SRC (50))
Project Start
1994-08-01
Project End
1997-11-30
Budget Start
1997-08-01
Budget End
1997-11-30
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Pediatrics
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143