Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Physician Scientist Award (K11)
Project #
5K11DK002379-02
Application #
2134319
Study Section
Special Emphasis Panel (SRC)
Project Start
1995-07-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Kruglov, Emma A; Nathanson, Rebecca A; Nguyen, Trong et al. (2006) Secretion of MCP-1/CCL2 by bile duct epithelia induces myofibroblastic transdifferentiation of portal fibroblasts. Am J Physiol Gastrointest Liver Physiol 290:G765-71
Jhandier, M Nauman; Kruglov, Emma A; Lavoie, Elise G et al. (2005) Portal fibroblasts regulate the proliferation of bile duct epithelia via expression of NTPDase2. J Biol Chem 280:22986-92
Dranoff, Jonathan A; Kruglov, Emma A; Toure, Joahd et al. (2004) Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis. J Investig Med 52:475-82
Dranoff, Jonathan A; Ogawa, Mika; Kruglov, Emma A et al. (2004) Expression of P2Y nucleotide receptors and ectonucleotidases in quiescent and activated rat hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 287:G417-24
Wells, Rebecca G; Kruglov, Emma; Dranoff, Jonathan A (2004) Autocrine release of TGF-beta by portal fibroblasts regulates cell growth. FEBS Lett 559:107-10
Dranoff, Jonathan A; Kruglov, Emma A; Robson, Simon C et al. (2002) The ecto-nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver. Hepatology 36:1135-44
Kruglov, Emma A; Jain, Dhanpat; Dranoff, Jonathan A (2002) Isolation of primary rat liver fibroblasts. J Investig Med 50:179-84
Teckman, J H; Gilmore, R; Perlmutter, D H (2000) Role of ubiquitin in proteasomal degradation of mutant alpha(1)-antitrypsin Z in the endoplasmic reticulum. Am J Physiol Gastrointest Liver Physiol 278:G39-48
Qu, D; Teckman, J H; Perlmutter, D H (1997) Review: alpha 1-antitrypsin deficiency associated liver disease. J Gastroenterol Hepatol 12:404-16
Teckman, J H; Qu, D; Perlmutter, D H (1996) Molecular pathogenesis of liver disease in alpha1-antitrypsin deficiency. Hepatology 24:1504-16

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