Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (K11)
Project #
5K11HD001049-03
Application #
2194599
Study Section
Special Emphasis Panel (SRC (CT))
Project Start
1994-01-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Neurology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Constantinescu, Cris S; Tani, Marie; Ransohoff, Richard M et al. (2005) Astrocytes as antigen-presenting cells: expression of IL-12/IL-23. J Neurochem 95:331-40
Constantinescu, C S; Hilliard, B; Ventura, E et al. (2001) Modulation of susceptibility and resistance to an autoimmune model of multiple sclerosis in prototypically susceptible and resistant strains by neutralization of interleukin-12 and interleukin-4, respectively. Clin Immunol 98:23-30
Constantinescu, C S; Lavi, E (2000) Anterior uveitis in murine relapsing experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS). Curr Eye Res 20:71-6
Constantinescu, C S; Goodman, D B; Hilliard, B et al. (2000) Murine macrophages stimulated with central and peripheral nervous system myelin or purified myelin proteins release inflammatory products. Neurosci Lett 287:171-4
Constantinescu, C S; Hilliard, B; Wysocka, M et al. (1999) IL-12 reverses the suppressive effect of the CD40 ligand blockade on experimental autoimmune encephalomyelitis (EAE). J Neurol Sci 171:60-4
Constantinescu, C S; Wysocka, M; Hilliard, B et al. (1998) Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis. J Immunol 161:5097-104
Constantinescu, C S; Goodman, D B; Ventura, E S (1998) Captopril and lisinopril suppress production of interleukin-12 by human peripheral blood mononuclear cells. Immunol Lett 62:25-31
Constantinescu, C S; Hilliard, B; Fujioka, T et al. (1998) Pathogenesis of neuroimmunologic diseases. Experimental models. Immunol Res 17:217-27
Constantinescu, C S; Fujioka, T; Kolson, D L et al. (1998) Absence of electromyographically detectable acute neuromuscular transmission defects after intramuscular interferon-gamma administration. J Neurol 245:333-4
Constantinescu, C S; Hilliard, B; Ventura, E et al. (1997) Luzindole, a melatonin receptor antagonist, suppresses experimental autoimmune encephalomyelitis. Pathobiology 65:190-4

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