Abstract

This is an renewal application for a physician scientist training program at the University of California San Diego, currently in its eighth year. The application was submitted for review at the June 1994 meeting of the Biological and Clinical Aging Review Committee B but was deferred pending receipt of further information from the program director. Many of the concerns of the committee related to an absence of a focus on aging and failure of integration with clinical geriatrics, two issues raised at the previous review (March 92) and which did not appear to be addressed in the renewal application. The Director of the program was invited to respond to these concerns and his answers were supplied to the reviewers for the October meeting where the application was again considered. The following critique focusses, in part, on the response of the Director to those concerns.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
2K12AG000353-09
Application #
2048106
Study Section
Biological and Clinical Aging Review Committee (BCA)
Project Start
1987-08-01
Project End
1996-08-31
Budget Start
1995-09-14
Budget End
1996-08-31
Support Year
9
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

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Fakhrai, H; Shawler, D L; Van Beveren, C et al. (1997) Construction and characterization of retroviral vectors for interleukin-2 gene therapy. J Immunother 20:437-48
Brugge, K L; Nichols, S L; Salmon, D P et al. (1994) Cognitive impairment in adults with Down's syndrome: similarities to early cognitive changes in Alzheimer's disease. Neurology 44:232-8
Samuel, W; Masliah, E; Hill, L R et al. (1994) Hippocampal connectivity and Alzheimer's dementia: effects of synapse loss and tangle frequency in a two-component model. Neurology 44:2081-8
Nguyen, V; Schonthal, A; Feldman, S T (1994) Expression of c-jun proto-oncogene in corneal endothelium. Exp Eye Res 59:335-41
Feldman, S T; Gately, D; Seely, B L et al. (1993) Stimulation of DNA synthesis and c-fos expression in corneal endothelium by insulin or insulin-like growth factor-I. Invest Ophthalmol Vis Sci 34:2105-11
Brugge, K L; Grove, G L; Clopton, P et al. (1993) Evidence for accelerated skin wrinkling among developmentally delayed individuals with Down's syndrome. Mech Ageing Dev 70:213-25
Sosnowski, R G; Feldman, S; Feramisco, J R (1993) Interference with endogenous ras function inhibits cellular responses to wounding. J Cell Biol 121:113-9
Gonzalez, G A; Feldman, S T (1993) Cyclic AMP mediated gene expression in bovine corneal endothelial cells. Invest Ophthalmol Vis Sci 34:2970-5
Feldman, S T; Gjerset, R; Gately, D et al. (1993) Expression of SV40 virus large T antigen by recombinant adenoviruses activates proliferation of corneal endothelium in vitro. J Clin Invest 91:1713-20

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