Abstract

This application seeks support for the initiation of a Physician-Scientist Program in Neurogerontology at the University of Southern California (USC). This is a joint effort of the Department of Neurology at the School of Medicine an the Neurogerontology Division of the Andrus Gerontology Center. Other USC sponsors are members of the Department of Psychiatry and the Neural Informational and Behavioral Sciences (NIBS) program. The proposed program encompasses both the basic and clinical research training in neuroscience with laboratory as well as didactic experiences. Candidates will be recruited from among physicians interested in academic careers in geriatric neurology, geriatric psychiatry and geriatric medicine. The physician scientists will have both a primary sponsor and a secondary clinical sponsor. The initial phase (I) will largely focus on the techniques and approaches to basic neuroscience research and will be conducted at the Neurogerontology Division of the andrus Gerontology Center and the NIBS program. In addition to the laboratory experiences, the candidate will enroll in required and elective courses in the neurosciences, neurogerontology, gerontology and molecular genetics that are appropriate for his/her expertise and needs. Other enrichment activities will include a weekly neurogerontology seminar at the Andrus Gerontology Center and a yearly neurogerontology retreat. In the second phase (II), the candidate will focus more on clinical neuroscience research related to Alzheimer's and/or Parkinson's diseases and be located either at the Health Sciences campus or the Andrus Gerontology Center. Physician scientists will meet regularly with Drs. Weiner and Schneider who will advise them on their choice of courses and insure that they are making adequate progress in their research programs. The decision to move a candidate from phase I to phase II will be made by the Physician Scientist Advisory Panel chaired by Dr. Weiner and comprised of all the potential sponsors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12AG000521-04
Application #
2048247
Study Section
Biological and Clinical Aging Review Committee (BCA)
Project Start
1991-08-09
Project End
1996-07-31
Budget Start
1994-08-01
Budget End
1995-07-31
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of Southern California
Department
Neurology
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Holschneider, D P; Scremin, O U; Huynh, L et al. (2000) Regional cerebral cortical activation in monoamine oxidase A-deficient mice: differential effects of chronic versus acute elevations in serotonin and norepinephrine. Neuroscience 101:869-77
Holschneider, D P; Leuchter, A F (2000) Attenuation of brain high frequency electrocortical response after thiopental in early stages of Alzheimer's dementia. Psychopharmacology (Berl) 149:11-Jun
Scremin, O U; Holschneider, D P; Chen, K et al. (1999) Cerebral cortical blood flow maps are reorganized in MAOB-deficient mice. Brain Res 824:36-44
Grewal, R P (1999) Neurodegeneration in Xeroderma Pigmentosum: a trinucleotide repeat mutation analysis. J Neurol Sci 163:183-6
Grewal, R P; Karkera, J D; Grewal, R K et al. (1999) Mutation analysis of oculopharyngeal muscular dystrophy in Hispanic American families. Arch Neurol 56:1378-81
Holschneider, D P; Leuchter, A F (1999) Clinical neurophysiology using electroencephalography in geriatric psychiatry: neurobiologic implications and clinical utility. J Geriatr Psychiatry Neurol 12:150-64
Grewal, R P; Cancel, G; Leeflang, E P et al. (1999) French Machado-Joseph disease patients do not exhibit gametic segregation distortion: a sperm typing analysis. Hum Mol Genet 8:1779-84
Grewal, R P; Morgan, T E; Finch, C E (1999) C1qB and clusterin mRNA increase in association with neurodegeneration in sporadic amyotrophic lateral sclerosis. Neurosci Lett 271:65-7
Holschneider, D P; Scremin, O U; Huynh, L et al. (1999) Lack of protection from ischemic injury of monoamine oxidase B-deficient mice following middle cerebral artery occlusion. Neurosci Lett 259:161-4
Holschneider, D P; Scremin, O U; Chen, K et al. (1999) Lack of protection of monoamine oxidase B-deficient mice from age-related spatial learning deficits in the Morris water maze. Life Sci 65:1757-63

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