Abstract

The institutional Physician Scientist Program at Yale University School of Medicine is organized to provide in depth research training to candidate physicians in four general areas of basic research: 1) Cell Biology; 2) Immunology; 3) Molecular Genetics and 4) Physiology of Membrane Transport. Phase I of the Program will consist of three years of intensive basic research training in the laboratory of a sponsor who is a member of the faculty of one of the basic science departments at Yale University. In addition to laboratory research, candidates in Phase I will follow an assigned curriculum of graduate school courses related to one of the four research areas listed above. Phase II of the program (2 years) will consist of the application of the research training obtained in Phase I to clinical investigative research within one of the subspecialty sections of one of the clinical departments of the medical school, with particular emphasis in the areas of rheumatology, endocrinology, diabetes, metabolic diseases, nephrology, hematology and gastroenterology and additional opportunities in dermatology, urology and orthopedic surgery.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
3K12DK001423-05S3
Application #
3088179
Study Section
Special Emphasis Panel (SRC)
Project Start
1985-07-01
Project End
1994-06-30
Budget Start
1992-08-20
Budget End
1994-06-30
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Bockenstedt, L K; Fikrig, E; Barthold, S W et al. (1996) Identification of a Borrelia burgdorferi OspA T cell epitope that promotes anti-OspA IgG in mice. J Immunol 157:5496-502
Bockenstedt, L K; Gee, R J; Mamula, M J (1995) Self-peptides in the initiation of lupus autoimmunity. J Immunol 154:3516-24
Burn, T C; Connors, T D; Dackowski, W R et al. (1995) Analysis of the genomic sequence for the autosomal dominant polycystic kidney disease (PKD1) gene predicts the presence of a leucine-rich repeat. The American PKD1 Consortium (APKD1 Consortium). Hum Mol Genet 4:575-82
Fikrig, E; Bockenstedt, L K; Barthold, S W et al. (1994) Sera from patients with chronic Lyme disease protect mice from Lyme borreliosis. J Infect Dis 169:568-74
Kraus, B; Pohlschmidt, M; Leung, A L et al. (1994) A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1). Genomics 24:27-33
Bockenstedt, L K; Barthold, S; Deponte, K et al. (1993) Borrelia burgdorferi infection and immunity in mice deficient in the fifth component of complement. Infect Immun 61:2104-7
Barthold, S W; Bockenstedt, L K (1993) Passive immunizing activity of sera from mice infected with Borrelia burgdorferi. Infect Immun 61:4696-702
Germino, G G; Somlo, S (1993) Inherited diseases of the kidney. Curr Opin Nephrol Hypertens 2:430-40
Bockenstedt, L K; Fikrig, E; Barthold, S W et al. (1993) Inability of truncated recombinant Osp A proteins to elicit protective immunity to Borrelia burgdorferi in mice. J Immunol 151:900-6
Germino, G G; Somlo, S; Weinstat-Saslow, D et al. (1993) Positional cloning approach to the dominant polycystic kidney disease gene, PKD1. Kidney Int Suppl 39:S20-5

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