This application seeks support for our competing renewal application for the Multidisciplinary K12 Urologic Research (KURe) Career Development Program to the Scott Department of Urology and the Center for Reproductive Medicine at Baylor College of Medicine. The research emphasis of this program is in the areas pediatric urology/genitourinary development, steroid hormone action, stem cells genetics and lower urinary tract symptoms (LUTS). The training faculty includes 7 Ph.D/M.D., Ph.D. faculty and11 M.D.s. Dr. Lamb will serve as both the Program Director and the Administrative Director of the KURe career development program. Dr. Boone will serve as co-Director. Drs. Lipshultz, Cunningham, Gonzales, Khera, Roth, Janzen will ensure the M.D. trainees are optimally trained in the urologic subspecialty areas of men's health and pediatric urology. The major research areas in the program include: genetics and genomics of genitourinary developmental defects, cell biology, steroid hormone receptors, male reproductive tract biology, genetics, cell cycle control, stem cells, gene therapy and LUTS. The trainees will be M.D. and Ph.D. junior faculty members at Baylor College of Medicine. Our program attracts highly qualified trainees who seek intensive and substantial research training in urology research with an emphasis on clinical translation. We have a defined recruitment plan that emphasizes the recruitment of women and minorities. The strengths of the training environment include highly respected, well-funded, experienced faculty, the high ranking national ranking for NIH funding of a Urology/Cell Biology/Genetics/Pathology departments, a structured mentoring program with required coursework, a cell biology graduate program with relevant course work and depth in both cell biology and genetics. Most importantly, we have a strong track record of training successful physician scientists. Our long- term goal is to train these young investigators to successfully compete for peer-reviewed funding and eventually to increase basic and translational research efforts in men's reproductive health research.

Public Health Relevance

This KURe K12 application will train new investigators to become clinical and basic researchers in urologic health issues. This program will offer training in both basic and clinical research to investigators to improve urologic health.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Physician Scientist Award (Program) (PSA) (K12)
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Special Emphasis Panel (ZDK1-GRB-R (M3))
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Rankin, Tracy L
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Baylor College of Medicine
Schools of Medicine
United States
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Thirumavalavan, Nannan; Hoover, Christopher R V; Gross, Martin S (2018) Surgeons Corner: Cavernoscopy for Rear Tip Extender Removal. J Sex Med 15:1195-1197
Thirumavalavan, Nannan; Scovell, Jason M; Balasubramanian, Adithya et al. (2018) The Impact of Microsurgical Repair of Subclinical and Clinical Varicoceles on Total Motile Sperm Count: Is There a Difference? Urology 120:109-113
Gabrielsen, J Scott; Lamb, Dolores J; Lipshultz, Larry I (2018) Iron and a Man's Reproductive Health: the Good, the Bad, and the Ugly. Curr Urol Rep 19:60
White, Jeffrey T; Sheth, Kunj R; Bilgutay, Aylin E et al. (2018) Vesicoamniotic Shunting Improves Outcomes in a Subset of Prune Belly Syndrome Patients at a Single Tertiary Center. Front Pediatr 6:180
Thirumavalavan, Nannan; Cordon, Billy H; Gross, Martin S et al. (2018) Rear Tip Extenders and Penile Prosthesis Rigidity: A Laboratory Study of Coloplast Prostheses. J Sex Med 15:1030-1033
Thirumavalavan, Nannan; Scovell, Jason M; Link, Richard E et al. (2018) Does Solid Organ Transplantation Affect Male Reproduction? Eur Urol Focus 4:307-310
High, Rachel; Kavanagh, Alex; Khavari, Rose et al. (2018) Procedure Choice in Primary Versus Recurrent Prolapse: A Study of Fellowship-Trained Surgeons. Female Pelvic Med Reconstr Surg 24:277-280
Butaney, Mohit; Thirumavalavan, Nannan; Hockenberry, Mark S et al. (2018) Variability in penile duplex ultrasound international practice patterns, technique, and interpretation: an anonymous survey of ISSM members. Int J Impot Res 30:237-242
Alge, Joseph L; Wenderfer, Scott E; Hicks, John et al. (2017) Hemolytic uremic syndrome as the presenting manifestation of WT1 mutation and Denys-Drash syndrome: a case report. BMC Nephrol 18:243
Kaviani, Aaron; Khavari, Rose (2017) Disease-Specific Outcomes of Botulinum Toxin Injections for Neurogenic Detrusor Overactivity. Urol Clin North Am 44:463-474

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