The goal of this Career Development Program is to develop a new generation of pediatric endocrinologists who will be equipped to carry out innovative, scientifically rigorous patient-oriented and laboratory-based research related to diabetes mellitus in children. The need for this Program derives from the critical shortage of academic pediatric endocrinologists working in diabetes research, which has been emphasized by organizations such as the American Diabetes Association, Juvenile Diabetes Research Foundation, and Pediatric Academic Societies. In addition, this Program recognizes the important new opportunities for advancing diabetes research in children provided by such pivotal scientific advances as the Human Genome Project, and improved success in islet transplantation and the production of biomechanical and bio-engineered islets. This K12 Program will support Scholars for up to 3 years of research career development at the junior faculty level. The Program faculty includes 32 scientific mentors from the Children's Hospital and the U Penn School of Medicine who have outstanding credentials, active research programs and training records. These mentors will supervise Scholars'career development through basic laboratory and/or patient- oriented research related to diabetes in children. Career development opportunities will include 3 major areas of basic research 1) Signal Transduction: Mechanisms of Hormone Action;2) Regulation of Pancreatic beta-Cell Function and Development;and 3) Genetic Approaches to Diabetes and Endocrine Diseases. Patient-oriented research opportunities will include the areas of 1) Islet Immunology, Transplantation, and Regulation;2) Therapeutic Approaches to Islet Cell Preservation 3) Obesity and Insulin Resistance, 4) Diabetes Complications;and 5) Diabetes Epidemiology and Biostatistics. The Program includes a curriculum of formal training in all aspects of research;(including biostatistics, bioethics, molecular biology, etc.) and is strongly supported by access to a superb range of institutional resources, including the CHOP CTRC and the UPenn DERC.

Public Health Relevance

In the United States, medical research progress in pediatric diabetes has been hampered by a shortage of physicians who are trained to perform patient- oriented and laboratory-based research related to diabetes in children. The Children's Hospital of Philadelphia has consistently produced highly skilled researchers in pediatric diabetes and related conditions. This grant will provide funds to support promising young physicians as they develop the skills needed to become successful in their field.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12DK094723-03
Application #
8532895
Study Section
Special Emphasis Panel (ZDK1-GRB-C (O2))
Program Officer
Hyde, James F
Project Start
2011-09-16
Project End
2015-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
3
Fiscal Year
2013
Total Cost
$514,379
Indirect Cost
$38,102
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Gordon, Rebecca J; Levine, Michael A (2018) Genetic Disorders of Parathyroid Development and Function. Endocrinol Metab Clin North Am 47:809-823
Polyak, Erzsebet; Ostrovsky, Julian; Peng, Min et al. (2018) N-acetylcysteine and vitamin E rescue animal longevity and cellular oxidative stress in pre-clinical models of mitochondrial complex I disease. Mol Genet Metab 123:449-462
Herrera, Adriana; Vajravelu, Mary Ellen; Givler, Stephanie et al. (2018) Prevalence of Adverse Events in Children With Congenital Hyperinsulinism Treated With Diazoxide. J Clin Endocrinol Metab 103:4365-4372
Roizen, Jeffrey D; Li, Dong; O'Lear, Lauren et al. (2018) CYP3A4 mutation causes vitamin D-dependent rickets type 3. J Clin Invest 128:1913-1918
Stanescu, Diana E; Yu, Reynold; Won, Kyoung-Jae et al. (2017) Single cell transcriptomic profiling of mouse pancreatic progenitors. Physiol Genomics 49:105-114
Weber, D R; Stark, L J; Ittenbach, R F et al. (2017) Building better bones in childhood: a randomized controlled study to test the efficacy of a dietary intervention program to increase calcium intake. Eur J Clin Nutr 71:788-794
Xi, Dong; Long, Caela; Lai, Meizan et al. (2017) Ablation of Oxytocin Neurons Causes a Deficit in Cold Stress Response. J Endocr Soc 1:1041-1055
Tiyaboonchai, Amita; Cardenas-Diaz, Fabian L; Ying, Lei et al. (2017) GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic ? Cells. Stem Cell Reports 8:589-604
McCormack, Shana E; Chesi, Alessandra; Mitchell, Jonathan A et al. (2017) Relative Skeletal Maturation and Population Ancestry in Nonobese Children and Adolescents. J Bone Miner Res 32:115-124
Kwon, Young Joon; Allen, Julian L; Liu, Grant T et al. (2016) Presumed Pseudotumor Cerebri Syndrome After Withdrawal of Inhaled Glucocorticoids. Pediatrics 137:

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