Abstract

The overall theme of the WRHR Center will be to emphasize a fundamental approach to the diseases of women that include the disciplines of developmental biology, molecular genetics and cell biology, behavioral science as well as translational and clinical investigative research. All of the proposed faculty mentors will be able to provide training to allow the WRHR scholars to establish their own independent, fundable research programs applicable to the clinical problems of women. No core laboratory in the WRHR Center is being requested as core laboratory facilities will be made available for use in departments where the faculty mentors are situated. The impact of the UCLA WRHR Center has extended beyond the New Program Development Awardees and has been felt by the faculty mentors in Obstetrics and Gynecology on each of the participating UCLA campuses. This has facilitated the recruitment of medical students, house officers and fellows into investigative basic and clinical research related to Women's Reproductive Health. In view of the multidisciplinary approach of the activities of the Center, we have observed that faculty mentors from other departments who are a part of the mentor pool better appreciate the problems related to Women's Reproductive Health and have been stimulated to work in this area of investigation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD001281-10
Application #
7501289
Study Section
Special Emphasis Panel (ZHD1-DSR-A (20))
Program Officer
Parrott, Estella C
Project Start
1998-09-30
Project End
2011-06-30
Budget Start
2008-07-01
Budget End
2011-06-30
Support Year
10
Fiscal Year
2008
Total Cost
$400,000
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Janzen, C; Lei, M Y Y; Cho, J et al. (2013) Placental glucose transporter 3 (GLUT3) is up-regulated in human pregnancies complicated by late-onset intrauterine growth restriction. Placenta 34:1072-8
Fekete, Mirela; Santiskulvong, Chintda; Eng, Carol et al. (2012) Effect of PI3K/Akt pathway inhibition-mediated G1 arrest on chemosensitization in ovarian cancer cells. Anticancer Res 32:445-52
Kuo, John; Micevych, Paul (2012) Neurosteroids, trigger of the LH surge. J Steroid Biochem Mol Biol 131:57-65
Janzen, Carla; Sen, Suvajit; Cuevas, Janis et al. (2011) Protein phosphatase 2A promotes endothelial survival via stabilization of translational inhibitor 4E-BP1 following exposure to tumor necrosis factor-?. Arterioscler Thromb Vasc Biol 31:2586-94
Santiskulvong, Chintda; Konecny, Gottfried E; Fekete, Mirela et al. (2011) Dual targeting of phosphoinositide 3-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach in human ovarian carcinoma. Clin Cancer Res 17:2373-84
Karam, Amer K; Santiskulvong, Chintda; Fekete, Mirela et al. (2010) Cisplatin and PI3kinase inhibition decrease invasion and migration of human ovarian carcinoma cells and regulate matrix-metalloproteinase expression. Cytoskeleton (Hoboken) 67:535-44
Ambartsumyan, Gayane; Gill, Rajbir K; Perez, Silvia Diaz et al. (2010) Centromere protein A dynamics in human pluripotent stem cell self-renewal, differentiation and DNA damage. Hum Mol Genet 19:3970-82
Kuo, J; Hariri, O R; Micevych, P (2009) An interaction of oxytocin receptors with metabotropic glutamate receptors in hypothalamic astrocytes. J Neuroendocrinol 21:1001-6
Kuo, John; Hariri, Omid R; Bondar, Galyna et al. (2009) Membrane estrogen receptor-alpha interacts with metabotropic glutamate receptor type 1a to mobilize intracellular calcium in hypothalamic astrocytes. Endocrinology 150:1369-76
Chin, Mark H; Mason, Mike J; Xie, Wei et al. (2009) Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell 5:111-23

Showing the most recent 10 out of 17 publications