This application seeks ongoing support for the University of Iowa Child Health Research Career development program in response to RFA HD-00-020. The purpose is to support the research career development of pediatricians who have recently completed subspecialty training. The application is to continue a program that provides core support for laboratories and administrative resources applicable to a number of research projects that address the molecular biology of development. These include the identification and localization of genes in the human genome, mechanisms by which specific genes regulate the synthesis of gene products, and gene targeting and gene transfer to study gene function in developing tissues. The P.I., Program Director, and Established Investigators whose funded research is closely related to the focus of the CHRCDA will act as an advisory committee to select from highly qualified new faculty pediatrician scientists three recipients of New Project Development Funds at all times. Each of the Scholars will conduct investigations under guidance of one or more identified Established Investigators. Each will perform molecular biologic procedures in a Shared Core Laboratory that is supported in part by University matching funds and is under the supervision of a Core Laboratory Director. Scholars supported by the award also may spend other periods of time working in the laboratories of their respective Established Investigators. This arrangement will provide cost-effective, quality- controlled, instrumentation and procedure performance to Scholars. Scholars will attend lectures, seminars and formal graduate courses on research ethics, as well as on molecular biology techniques and strategies in developmental biology. Measures to attract women and minority pediatricians to research careers have been incorporated. The program is anticipated to capitalize on an institutional infrastructure of interdisciplinary research and will build upon a departmental tradition of research career development. It will promote productivity and collaboration, and speed the application of new basic science discoveries to clinical care.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Physician Scientist Award (Program) (PSA) (K12)
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Application #
Study Section
Special Emphasis Panel (ZHD1-DSR-A (12))
Program Officer
Winer, Karen
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University of Iowa
Schools of Medicine
Iowa City
United States
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Boes, Aaron D; Fischer, David; Geerling, Joel C et al. (2018) Connectivity of sleep- and wake-promoting regions of the human hypothalamus observed during resting wakefulness. Sleep 41:
Boes, Aaron D; Uitermarkt, Brandt D; Albazron, Fatimah M et al. (2018) Rostral anterior cingulate cortex is a structural correlate of repetitive TMS treatment response in depression. Brain Stimul 11:575-581
Meyer, Lauritz R; Dexter, Benjamin; Lo, Cecilia et al. (2018) Perinatal SSRI exposure permanently alters cerebral serotonin receptor mRNA in mice but does not impact adult behaviors. J Matern Fetal Neonatal Med 31:1393-1401
Zepeda-Orozco, Diana; Wen, Hsiang M; Hamilton, Bradley A et al. (2017) EGF regulation of proximal tubule cell proliferation and VEGF-A secretion. Physiol Rep 5:
Kaye, Harper L; Gersner, Roman; Boes, Aaron D et al. (2017) Persistent uncrossed corticospinal connections in patients with intractable focal epilepsy. Epilepsy Behav 75:66-71
Kelly, Michael S; Oliveira-Maia, Albino J; Bernstein, Margo et al. (2017) Initial Response to Transcranial Magnetic Stimulation Treatment for Depression Predicts Subsequent Response. J Neuropsychiatry Clin Neurosci 29:179-182
Haskell, Sarah E; Lo, Cecilia; Kent, Mitchell E et al. (2017) Cardiac Outcomes After Perinatal Sertraline Exposure in Mice. J Cardiovasc Pharmacol 70:119-127
Brumbaugh, Jane E; Conrad, Amy L; Lee, Jessica K et al. (2016) Altered brain function, structure, and developmental trajectory in children born late preterm. Pediatr Res 80:197-203
Manoli, Irini; Myles, Jennifer G; Sloan, Jennifer L et al. (2016) A critical reappraisal of dietary practices in methylmalonic acidemia raises concerns about the safety of medical foods. Part 1: isolated methylmalonic acidemias. Genet Med 18:386-95
Schofield, Thomas J; Conger, Rand D; Gonzales, Joseph E et al. (2016) Harsh parenting, physical health, and the protective role of positive parent-adolescent relationships. Soc Sci Med 157:18-26

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