The Oregon CHRC was created in 1996 as a new and developing center. It has since funded eight Junior Investigators. The center has achieved its success through the success of its trainees. Seven of the trainees have procured funding from the NIH, and all eight have obtained funding independent of the Oregon CHRC program. The activities of the Junior Investigators have been facilitated by a group of senior faculty who comprise the Advisory Committee and core of Established Investigators. These scientists represent a variety of training facilities in Portland, and have diverse areas of interest that are of relevance to the Pediatric Investigator. All of the participants have a strong history of training, and are to be involved in the creation of future Pediatric Physician-Scientists. CHRC funding has been used to establish an exceptional Core Laboratory within the Department of Pediatrics. The Core Laboratory encompasses the gamut of molecular biology methodologies and expertise, including tissue culture DNA sequencing, gene discovery with microarray technology, and a state-of-the-art functional genomics component to be developed as part of the current proposal. An effective formal educational program has been implemented and will be provided during the first two years of training for each Junior Investigator.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD033703-08
Application #
6648338
Study Section
Special Emphasis Panel (ZHD1-MCHG-B (10))
Program Officer
Winer, Karen
Project Start
1996-02-15
Project End
2005-11-30
Budget Start
2002-12-01
Budget End
2003-11-30
Support Year
8
Fiscal Year
2003
Total Cost
$410,400
Indirect Cost
Name
Oregon Health and Science University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Ren, Gongyi; Jacob, Robert F; Kaulin, Yuri et al. (2011) Alterations in membrane caveolae and BKCa channel activity in skin fibroblasts in Smith-Lemli-Opitz syndrome. Mol Genet Metab 104:346-55
Zhang, Zili; Zhong, Wenwei; Spencer, Doran et al. (2009) Interleukin-17 causes neutrophil mediated inflammation in ovalbumin-induced uveitis in DO11.10 mice. Cytokine 46:79-91
Tulenko, Thomas N; Boeze-Battaglia, Kathy; Mason, R Preston et al. (2006) A membrane defect in the pathogenesis of the Smith-Lemli-Opitz syndrome. J Lipid Res 47:134-43