The Department of Pediatrics of the College of Physicians and Surgeons seeks to renew an institutional CHRCDA program for training pediatricians in basic science or clinical research aimed at equipping the trainees with sufficient research skills and knowledge to prepare them for a research career in pediatrics. It specifically addresses the needs of pediatricians who have completed clinical training by providing a supportive but rigorous research training environment that will foster their commitment to a career in research and allow them to develop their skills as investigators. The career development program, which will continue to have a total of four to five career development scholars at one time, builds on the accomplishments of the Columbia Child Health Research Center as well as other training programs in the institution that seek to develop junior faculty to become independent investigators. It will be the keystone in a series of support mechanisms operating from the time of the completion of their residency training through their establishment as research-based junior faculty that should develop a strong junior faculty in pediatrics that can compete effectively for NIH funding. The program takes advantage of Columbia's strong basic science and clinical investigator faculty to provide an array of mentors capable of providing excellent mentorship to developing pediatric investigators. The primary emphasis of the program is to provide training in the disciplines of molecular biology/cell biology through didactic and mentored bench research experience that will enable the scholar to conceptualize the molecular mechanisms of pediatric disease at the level of the gene, its product, and the regulation of its expression. The scope of the research will range from patient oriented research with mentoring in clinical investigation and clinical research methods, exemplified by theactivities centered in the Irving Center for Clinical Research through to concerted fundamental bench research. Experience gained in guiding career development in the first period of the award will be applied to enhance the training experience and increase the likelihood of successful career development.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD043389-02
Application #
6752508
Study Section
Special Emphasis Panel (ZHD1-DSR-A (19))
Program Officer
Winer, Karen
Project Start
2003-05-28
Project End
2007-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
2
Fiscal Year
2004
Total Cost
$429,193
Indirect Cost
Name
Columbia University (N.Y.)
Department
Pediatrics
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Colombo, Sophie; de Sena-Tomás, Carmen; George, Vanessa et al. (2018) Nkx genes establish second heart field cardiomyocyte progenitors at the arterial pole and pattern the venous pole through Isl1 repression. Development 145:
Pradhan, Arjana; Zeng, Xin-Xin I; Sidhwani, Pragya et al. (2017) FGF signaling enforces cardiac chamber identity in the developing ventricle. Development 144:1328-1338
George, Vanessa; Colombo, Sophie; Targoff, Kimara L (2015) An early requirement for nkx2.5 ensures the first and second heart field ventricular identity and cardiac function into adulthood. Dev Biol 400:10-22
Targoff, Kimara L; Colombo, Sophie; George, Vanessa et al. (2013) Nkx genes are essential for maintenance of ventricular identity. Development 140:4203-13
Wilhelm, Michael; Kukekov, Nickolay V; Schmit, Travis L et al. (2012) Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein. J Biol Chem 287:2247-56
Garbarino, Jeanne; Padamsee, Mahajabeen; Wilcox, Lisa et al. (2009) Sterol and diacylglycerol acyltransferase deficiency triggers fatty acid-mediated cell death. J Biol Chem 284:30994-1005
Targoff, Kimara L; Schell, Thomas; Yelon, Deborah (2008) Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number. Dev Biol 322:314-21
Roman, Elizabeth; Osunkwo, Ifeyinwa; Militano, Olga et al. (2008) Liposomal amphotericin B prophylaxis of invasive mold infections in children post allogeneic stem cell transplantation. Pediatr Blood Cancer 50:325-30
Turkish, Aaron R (2008) Nonalcoholic fatty liver disease: emerging mechanisms and consequences. Curr Opin Clin Nutr Metab Care 11:128-33
Turkish, Aaron; Sturley, Stephen L (2007) Regulation of triglyceride metabolism. I. Eukaryotic neutral lipid synthesis: ""Many ways to skin ACAT or a DGAT"". Am J Physiol Gastrointest Liver Physiol 292:G953-7

Showing the most recent 10 out of 12 publications