The Department of Obstetrics, Gynecology, and Reproductive Sciences will establish the Yale Women's Reproductive Health Research (WRHR) Career Development Center with the goal of selecting outstanding novice or more experienced scientists for advanced training in basic, translational, or clinical science under the guidance of skilled scientific mentors. The Principal Investigator (PI) and Program Director (PD) will monitor the Scholars' academic progress toward research independence. Prospective Scholars will be selected from among our residents, subspecialty fellows, and junior faculty, as well as via national networking by the PI and PD, and via advertisements in professional journals, letters to program directors and Chairs, and postings at national meetings. A selection committee will select WRHR Scholars who exhibit exceptional promise and commitment to a career in women's health research. The PI/PD and Advisory Committee will be directly involved in the training, evaluation and academic development of each WRHR scholar. Department of Ob/Gyn mentors are experienced in career development and are outstanding scientists in fields related to Women's Reproductive Health. Core training in basic lab techniques and molecular biology along with a didactic program will be required for all WRHR Scholars and will include instruction in the responsible and ethical conduct of research. Each Scholar will be assigned departmental laboratory space with access to shared teaching and training cores. In order to encourage career development, each Scholar will have 75% time and salary directly covered by the Center. Scholars will receive research support for 2-5 years to underwrite costs while they obtain preliminary data and prepare grant applications. The Yale WRHR Center will be incorporated into the overall Yale Medical Center Program in Women's Health. Scholars will enter the Department of Ob/Gyn as Assistant Professors, with appropriate office and support staff. Clinical duties and responsibilities will relate directly to research interests. There will be three WRHR Scholars in the Department at any given time. Career development will span two to five years, depending on the Scholar's initial level of experience and particular training goals as a Scholar. The Yale WRHR Center aims to foster Scholars' development into established, independent investigators. Yale shall seek to retain as faculty Scholars who successfully complete an individualized training program at Yale and who have made significant progress toward independent funding.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD047018-02
Application #
6891445
Study Section
Special Emphasis Panel (ZHD1-DSR-A (20))
Program Officer
Parrott, Estella C
Project Start
2004-05-01
Project End
2009-04-30
Budget Start
2005-05-01
Budget End
2006-04-30
Support Year
2
Fiscal Year
2005
Total Cost
$400,000
Indirect Cost
Name
Yale University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Mak, Winifred; Xia, Jing; Cheng, Ee-Chun et al. (2018) A role of Pumilio 1 in mammalian oocyte maturation and maternal phase of embryogenesis. Cell Biosci 8:54
Li, Fei; Alderman 3rd, Myles H; Tal, Aya et al. (2018) Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis. Stem Cells 36:881-890
Collins, Stephen C; Xu, Xiao; Mak, Winifred (2017) Cost-effectiveness of preimplantation genetic screening for women older than 37 undergoing in vitro fertilization. J Assist Reprod Genet 34:1515-1522
Mak, Winifred; Kondapalli, Laxmi A; Celia, Gerard et al. (2016) Natural cycle IVF reduces the risk of low birthweight infants compared with conventional stimulated IVF. Hum Reprod 31:789-94
Grimstad, F W; Nangia, Ajay K; Luke, B et al. (2016) Use of ICSI in IVF cycles in women with tubal ligation does not improve pregnancy or live birth rates. Hum Reprod 31:2750-2755
Whicker, Margaret E; Lin, Z Ping; Hanna, Ruth et al. (2016) MK-2206 sensitizes BRCA-deficient epithelial ovarian adenocarcinoma to cisplatin and olaparib. BMC Cancer 16:550
Ishiguro, Kimiko; Zhu, Yong-Lian; Lin, Z Ping et al. (2016) Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive ovarian carcinoma cell lines. J Transl Sci 2:117-124
Ratner, Elena S; Zhu, Yong-Lian; Penketh, Philip G et al. (2016) Triapine potentiates platinum-based combination therapy by disruption of homologous recombination repair. Br J Cancer 114:777-86
Mak, Winifred; Fang, Caodi; Holden, Tobias et al. (2016) An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline. Biol Reprod 94:134
Silasi, Michelle; Cardenas, Ingrid; Kwon, Ja-Young et al. (2015) Viral infections during pregnancy. Am J Reprod Immunol 73:199-213

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