Prior research strongly suggests that patients with affective disorders have abnormalities in the functioning of one or more neurobiological systems. At a conference convened by the Clinical Research Branch, NIMH, these findings were reviewed and some of the factors which were impeding movement towards a more complete and integrated view of the functioning of neurobiological systems in patients with mania or depression were identified. As a result, the NIMH sponsored the development of a multiresearch center, collaborative approach to the study of the psychobiology of affective disorders. In this collaborative program, underway for several years, the major objectives have been the testing of a wide range of hypotheses which implicate neurochemistry in the etiology and maintenance of the affective disorders. In order to accomplish this, the focus has been upon: (a) the assessment of the functioning of several different types of biological systems in the same patient both before and during treatment; (b) obtaining a large number of patients and comparison subjects; and (c) the use across centers of standardized diagnostic categories and behavioral methodologies. During the preceding grant period the data have been consolidated and data analysis has begun. Preliminary results have been reported and a range of studies are in progress.
The specific aim of this proposal is the continuation of the testing of earlier, as well as current, hypotheses related to the behavioral and physiological pathology, as well as to treatment responsivity which may characterize depressed patients and differentiate them from healthy subjects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01MH038084-04S1
Application #
3553861
Study Section
(SRC)
Project Start
1982-09-01
Project End
1988-06-30
Budget Start
1987-09-15
Budget End
1988-06-30
Support Year
4
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Texas Health Science Center San Antonio
Department
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Swann, A C; Katz, M M; Bowden, C L et al. (1999) Psychomotor performance and monoamine function in bipolar and unipolar affective disorders. Biol Psychiatry 45:979-88
Maas, J W; Katz, M M; Koslow, S H et al. (1994) Adrenomedullary function in depressed patients. J Psychiatr Res 28:357-67
Swann, A C; Stokes, P E; Secunda, S K et al. (1994) Depressive mania versus agitated depression: biogenic amine and hypothalamic-pituitary-adrenocortical function. Biol Psychiatry 35:803-13
Swann, A C; Secunda, S K; Katz, M M et al. (1993) Specificity of mixed affective states: clinical comparison of dysphoric mania and agitated depression. J Affect Disord 28:81-9
Swann, A C; Stokes, P E; Casper, R et al. (1992) Hypothalamic-pituitary-adrenocortical function in mixed and pure mania. Acta Psychiatr Scand 85:270-4
Swann, A C; Secunda, S K; Koslow, S H et al. (1991) Mania: sympathoadrenal function and clinical state. Psychiatry Res 37:195-205
Kocsis, J H; Croughan, J L; Katz, M M et al. (1990) Response to treatment with antidepressants of patients with severe or moderate nonpsychotic depression and of patients with psychotic depression. Am J Psychiatry 147:621-4
Swann, A C; Berman, N; Frazer, A et al. (1990) Lithium distribution in mania: single-dose pharmacokinetics and sympathoadrenal function. Psychiatry Res 32:71-84
Bowden, C L; Koslow, S; Maas, J W et al. (1987) Changes in urinary catecholamines and their metabolites in depressed patients treated with amitriptyline or imipramine. J Psychiatr Res 21:111-28
Maas, J W; Koslow, S H; Davis, J et al. (1987) Catecholamine metabolism and disposition in healthy and depressed subjects. Arch Gen Psychiatry 44:337-44

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