Abstract

The major aim of this six-center collaborative study was to test hypotheses which implicate neurobiological mechanisms in the etiology and maintenance of the affective disorders. This collaborative approach was developed in order to provide a consortium of investigators having expertise in diverse disciplines to design and conduct the research. The study utilized uniform diagnostic criteria and behavioral methods, so as to assess the functioning of multiple biological systems in the same subjects. It provided for assessment during a baseline drug-free period and after four weeks of antidepressant drug treatment. This collaborative effort makes it possible to test earlier and current hypotheses, and to examine interactions across and among biological systems and behavior. All data analysis and the initial phase of hypothesis testing have been essentially completed. This grant application represents a request for a final period of support during which the second phase of the testing of hypotheses which involve two or more biological systems and behavior, will be brought to a conclusion.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01MH038084-07
Application #
3553865
Study Section
Special Emphasis Panel (SRCM (CD))
Project Start
1982-09-01
Project End
1993-06-30
Budget Start
1990-07-01
Budget End
1993-06-30
Support Year
7
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of Texas Health Science Center San Antonio
Department
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229

  Publications

Swann, A C; Katz, M M; Bowden, C L et al. (1999) Psychomotor performance and monoamine function in bipolar and unipolar affective disorders. Biol Psychiatry 45:979-88
Maas, J W; Katz, M M; Koslow, S H et al. (1994) Adrenomedullary function in depressed patients. J Psychiatr Res 28:357-67
Swann, A C; Stokes, P E; Secunda, S K et al. (1994) Depressive mania versus agitated depression: biogenic amine and hypothalamic-pituitary-adrenocortical function. Biol Psychiatry 35:803-13
Swann, A C; Secunda, S K; Katz, M M et al. (1993) Specificity of mixed affective states: clinical comparison of dysphoric mania and agitated depression. J Affect Disord 28:81-9
Swann, A C; Stokes, P E; Casper, R et al. (1992) Hypothalamic-pituitary-adrenocortical function in mixed and pure mania. Acta Psychiatr Scand 85:270-4
Swann, A C; Secunda, S K; Koslow, S H et al. (1991) Mania: sympathoadrenal function and clinical state. Psychiatry Res 37:195-205
Kocsis, J H; Croughan, J L; Katz, M M et al. (1990) Response to treatment with antidepressants of patients with severe or moderate nonpsychotic depression and of patients with psychotic depression. Am J Psychiatry 147:621-4
Swann, A C; Berman, N; Frazer, A et al. (1990) Lithium distribution in mania: single-dose pharmacokinetics and sympathoadrenal function. Psychiatry Res 32:71-84
Bowden, C L; Koslow, S; Maas, J W et al. (1987) Changes in urinary catecholamines and their metabolites in depressed patients treated with amitriptyline or imipramine. J Psychiatr Res 21:111-28
Maas, J W; Koslow, S H; Davis, J et al. (1987) Catecholamine metabolism and disposition in healthy and depressed subjects. Arch Gen Psychiatry 44:337-44

Showing the most recent 10 out of 16 publications