Our NICHD CHRCD, Training Program in Basic Science Child Health Research, will be conducted at the University of Colorado Denver Anschutz Medical Campus, School of Medicine, Department of Pediatrics. Our OVERALL GOAL is that after their training, our Scholars will have acquired the professional skills for productive academic research careers as independent investigators and will have the leadership capacity to make significant impacts in the field of Child Health Research, particularly in helping to make basic discoveries that then can be translated into translational research and ultimately improved clinical practice that benefits the health of children. To achieve these objectives and goal: 1. We will create leadership and training program structure that will establish through direction (steering committee) and guidance (advisory committee): rigorous criteria and processes for: recruitment of scholars, research mentors, and individual scholar advisory committees; required attributes and specific activities of research and career development training; evaluation of all aspects of the program 2. We will identify, recruit, and enlist potential Scholars from the most exceptional pediatric residents, subspecialty residents (fellows), and junior faculty with strong academic records who are highly motivated and committed to establishing an independent basic science research-oriented career in academic pediatrics. 3. We will place Scholars into basic science research mentored relationships with our nationally-renowned, outstanding research faculty, who are recognized as experts in their fields with proven records of excellence in research training and career development of young investigators. 4. We will involve the Scholars in a broad array of research and career development opportunities that encompass the spectrum of modern techniques needed for basic and translational science research. 5. We will develop excellently mentored, flexible, scholar-oriented, rigorous, and challenging Career Development and Education Programs with high standards for expected accomplishments and development of creative independent thinking, excellent science communication skills, and responsible professional conduct; on-going mentorship will help to ensure successful transition to research independence. 6. We will develop an Evaluation Program that will ensure, through frequent, rigorous review of scholar and faculty accomplishments, the success of the program and needs to improve and/or meet new research and training requirements and new challenges in the field of child health research.
Our NICHD CHRCDA 'Training Program in Basic Science Child Health Research,' will be conducted at the University of Colorado Denver Anschutz Medical Campus, School of Medicine, Department of Pediatrics. Our PRINCIPAL OBJECTIVES are first, to develop basic science research career development training programs for junior faculty in Pediatrics in an outstanding academic environment, and second, to use these programs to produce highly qualified physician scientists, who are well grounded in basic science research skills and are educated in collaborative and integrated approaches for translating basic discoveries into opportunities for clinical research. Our overall goal is that afer their training, our Scholars will have acquired the professional skills for productive academic research careers as independent investigators and will have the leadership capacity to make significant impacts in the field of Child Health Research, particularly in helping to make basic discoveries that then can be translated into improved clinical research and ultimately clinical practice that benefits the health of children.
|Branchford, B R; Stalker, T J; Law, L et al. (2018) The small-molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis. J Thromb Haemost 16:352-363|
|Lehmann, M; Ashworth, K; Manco-Johnson, M et al. (2018) Evaluation of a microfluidic flow assay to screen for von Willebrand disease and low von Willebrand factor levels. J Thromb Haemost 16:104-115|
|Lee-Sherick, Alisa B; Jacobsen, Kristen M; Henry, Curtis J et al. (2018) MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity. JCI Insight 3:|
|Ng, Christopher J; McCrae, Keith R; Ashworth, Katrina et al. (2018) Effects of anti-?2GPI antibodies on VWF release from human umbilical vein endothelial cells and ADAMTS13 activity. Res Pract Thromb Haemost 2:380-389|
|Baker 2nd, Peter R; Patinkin, Zachary W; Shapiro, Allison L B et al. (2017) Altered gene expression and metabolism in fetal umbilical cord mesenchymal stem cells correspond with differences in 5-month-old infant adiposity gain. Sci Rep 7:18095|
|Brown, Laura D; Kohn, Jaden R; Rozance, Paul J et al. (2017) Exogenous amino acids suppress glucose oxidation and potentiate hepatic glucose production in late gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol 312:R654-R663|
|Deng, Guiying; Orfila, James E; Dietz, Robert M et al. (2017) Autonomous CaMKII Activity as a Drug Target for Histological and Functional Neuroprotection after Resuscitation from Cardiac Arrest. Cell Rep 18:1109-1117|
|Benjamin, Joshua S; Culpepper, Christine B; Brown, Laura D et al. (2017) Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep. Am J Physiol Regul Integr Comp Physiol 312:R492-R500|
|Nakano, Stephanie J; Sucharov, Juliana; van Dusen, Robert et al. (2017) Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment. J Card Fail 23:72-80|
|Hoffman, Olivia; Burns, Nana; Vadász, István et al. (2017) Detrimental ELAVL-1/HuR-dependent GSK3? mRNA stabilization impairs resolution in acute respiratory distress syndrome. PLoS One 12:e0172116|
Showing the most recent 10 out of 46 publications