This application proposes to establish a multidisciplinary basic, translational, and clinical research training and career development program, the Oregon Health & Science University (OHSU) Women's Reproductive Health Research K12 Program, which will foster and cultivate a cadre of OB/GYN physicians to transition into leading independent physician-scientists in women's reproductive health. The program builds upon long-standing collaborations between the OB/GYN Department and prominent OHSU Centers, Institutes, and Departments, including the Oregon National Primate Research Center, and Knight Cardiovascular and Cancer Research Institutes, to provide a strong foundation for multidisciplinary training, mentorship, and research. The primary aim of the program is to produce highly-qualified OB/GYN researchers with a specific focus on the reproductive life cycle spanning the preconception period (including family planning) to developmental biology to pregnancy care and complications in both women and their offspring. The specific areas of emphasis would be: (1) contraceptive development, effectiveness, and impact; (2) developmental origins of health and disease (DOHaD) - fetal programming; (3) reproductive biology including ovarian and uterine function/dysfunction, the developing embryo and fetus; (4) maternal physiology, pathophysiology, pregnancy care and complications, and the outcomes of both women and their offspring. Upon completion of the OHSU WRHR K12 Program, scholars will have expertise in research methods and the skills required for success as academic physician-scientists in reproductive health. Scholars will develop content expertise relevant to his or her research interests, along with the specific research skills appropriate to that research topic as well as skills in scientific writing including grant writing and academic career development. By the end of the training period, each scholar will be well-prepared to become independently funded physician-scientists. With this in mind, the OHSU WRHR K12 Program has the following Specific Aims: 1) To attract and develop a diverse group of OB/GYN physician-scientists. 2) To train scholars across the span of the reproductive life cycle from contraception, to DOHaD, developmental biology, birth and beyond. 3) To train scholars along the spectrum of basic/translational/clinical research - from bench to bedside to clinical trials to health services research as applied to Women's Health Research.

Public Health Relevance

We will create a research training and career development program, the OHSU Women's Reproductive Health Research K12 Program, which will prepare obstetrician- gynecologists to become physician-scientists and develop independent research careers. It will be a multi-disciplinary effort pulling together mentor teams from throughout OHSU. The primary aim of the program is to produce highly qualified OB/GYN researchers who will conduct research across the reproductive life cycle.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Physician Scientist Award (Program) (PSA) (K12)
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Special Emphasis Panel (ZHD1)
Program Officer
Halvorson, Lisa M
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Oregon Health and Science University
Obstetrics & Gynecology
Schools of Medicine
United States
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Baldwin, Maureen K; Hart, Kyle D; Rodriguez, Maria I (2018) Predictors for follow-up among postpartum patients enrolled in a clinical trial. Contraception 98:228-231
Hainmueller, Jens; Lawrence, Duncan; Martén, Linna et al. (2017) Protecting unauthorized immigrant mothers improves their children's mental health. Science 357:1041-1044
Han, Leo; Han, Lisa; Darney, Blair et al. (2017) Tweeting PP: an analysis of the 2015-2016 Planned Parenthood controversy on Twitter. Contraception 96:388-394
Valent, Amy M; Peticca, Katie; DiMatteo, Alexandra et al. (2017) Pyelonephritis in Pregnancy: Prediction of Prolonged Hospitalization and Maternal Morbidity using Prognostic Scoring Systems. Am J Perinatol 34:1212-1218
Dilley, Sarah E; Havrilesky, Laura J; Bakkum-Gamez, Jamie et al. (2017) Cost-effectiveness of opportunistic salpingectomy for ovarian cancer prevention. Gynecol Oncol 146:373-379
Swartz, Jonas J; Hainmueller, Jens; Lawrence, Duncan et al. (2017) Expanding Prenatal Care to Unauthorized Immigrant Women and the Effects on Infant Health. Obstet Gynecol 130:938-945
Kolahi, Kevin S; Valent, Amy M; Thornburg, Kent L (2017) Cytotrophoblast, Not Syncytiotrophoblast, Dominates Glycolysis and Oxidative Phosphorylation in Human Term Placenta. Sci Rep 7:42941
Thornburg, Kent L; Kolahi, Kevin; Pierce, Melinda et al. (2016) Biological features of placental programming. Placenta 48 Suppl 1:S47-S53
Lee, V R; Darney, B G; Snowden, J M et al. (2016) Term elective induction of labour and perinatal outcomes in obese women: retrospective cohort study. BJOG 123:271-8
Bishop, Cecily V; Xu, Fuhua; Xu, Jing et al. (2016) Western-style diet, with and without chronic androgen treatment, alters the number, structure, and function of small antral follicles in ovaries of young adult monkeys. Fertil Steril 105:1023-34

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