? The objectives of the Clinical Hematology Research Career Development Program at Washington University are to develop and evaluate a multidisciplinary career development program that will prepare trainees (Scholars) to address complex problems in non-malignant blood diseases. Scholars will be clinical or research fellows, clinical or research instructors, or recently appointed assistant professors. Scholars are expected to become independent researchers and assume leadership roles in non-malignant clinical hematology. During the first year, Scholars will pursue a Clinical Core Curriculum that involves inpatient and outpatient care of patients with specific non-malignant hematologic disorders, and a Didactic Clinical Research Curriculum that teaches the skills necessary for independent and ethical clinical research. This first-year curriculum will draw on the strengths of existing K30 and degree granting programs in biostatistics, epidemiology, and clinical research at Washington University. Toward the end of the first year, each Scholar will begin a one or two year intensive Mentored Research Experience to generate publishable results and preliminary data for subsequent independent grant applications. The program will focus on three major areas of non-malignant hematologic disease: (1) bone marrow failure syndromes, including paroxysmal nocturnal hemoglobinuria, aplastic anemia, congenital anemias, and myleodysplastic syndrome; (2) hemostatic and thrombotic disorders, including von Willebrand disease, thrombotic microangiopathy, and other congenital or acquired hemorrhagic or thrombotic syndromes; and (3) sickle cell disease and other hemoglobinopathies. These research projects will encompass pediatric, adolescent and adult subjects with non-malignant hematologic disorders. Implicit in these objectives is our commitment to recruit outstanding Scholars from diverse backgrounds, to individualize their training based on their needs and experience, to continuously monitor and improve the curriculum, and to track Scholar performance. By these means, the proposed career development program will increase our national capacity for translational, multidisciplinary research in non-malignant clinical hematology and alleviate the shortage of academic physician-scientists in this medically important discipline. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HL087107-02
Application #
7291516
Study Section
Special Emphasis Panel (ZHL1-CSR-Z (S1))
Program Officer
Werner, Ellen
Project Start
2006-09-28
Project End
2011-08-31
Budget Start
2007-09-01
Budget End
2008-08-31
Support Year
2
Fiscal Year
2007
Total Cost
$389,242
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Rimando, Joseph; Slade, Michael; DiPersio, John F et al. (2018) HLA epitope mismatch in haploidentical transplantation is associated with decreased relapse and delayed engraftment. Blood Adv 2:3590-3601
Ford, Andria L; Ragan, Dustin K; Fellah, Slim et al. (2018) Silent infarcts in sickle cell disease occur in the border zone region and are associated with low cerebral blood flow. Blood 132:1714-1723
Liu, Chang; Xiao, Fangzhou; Hoisington-Lopez, Jessica et al. (2018) Accurate Typing of Human Leukocyte Antigen Class I Genes by Oxford Nanopore Sequencing. J Mol Diagn 20:428-435
Brestoff, Jonathan R; Vessoni, Alexandre T; Brenner, Kirsten A et al. (2018) Acute graft-versus-host disease following lung transplantation in a patient with a novel TERT mutation. Thorax 73:489-492
Trissal, Maria C; Wong, Terrence N; Yao, Juo-Chin et al. (2018) MIR142 Loss-of-Function Mutations Derepress ASH1L to Increase HOXA Gene Expression and Promote Leukemogenesis. Cancer Res 78:3510-3521
Fields, Melanie E; Guilliams, Kristin P; Ragan, Dustin K et al. (2018) Regional oxygen extraction predicts border zone vulnerability to stroke in sickle cell disease. Neurology 90:e1134-e1142
Guilliams, Kristin P; Fields, Melanie E; Ragan, Dustin K et al. (2018) Red cell exchange transfusions lower cerebral blood flow and oxygen extraction fraction in pediatric sickle cell anemia. Blood 131:1012-1021
Xiao, Daphne Y; Luo, Suhong; O'Brian, Katiuscia et al. (2017) Weight change trends and overall survival in United States veterans with follicular lymphoma treated with chemotherapy. Leuk Lymphoma 58:851-858
Fisher, D A C; Malkova, O; Engle, E K et al. (2017) Mass cytometry analysis reveals hyperactive NF Kappa B signaling in myelofibrosis and secondary acute myeloid leukemia. Leukemia 31:1962-1974
Liu, Chang; Pang, Sue; Phelan, Donna et al. (2017) Quantitative Evaluation of the Impact of Ethylenediaminetetraacetic Acid Pretreatment on Single-Antigen Bead Assay. Transplant Direct 3:e194

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