The goal of this program is to launch the careers of an outstanding group of next generation scientists equipped to use omics approaches to help transform lung research and pulmonary medicine. UCSF is one of the world's leading health sciences campuses and this program will build on existing strengths in pulmonary research, omics, and education and training. Two physician-scientists with experience in applying genomics and genetics tools to basic, translational and clinical pulmonary research will direct the program. An exceptionally accomplished group of mentors with strong records of interdisciplinary collaboration will bring complementary expertise in other key areas, including proteomics, microbiome research, metabolomics, computational biology, biostatistics, and career development program management. An Advisory Committee will work with the program directors to select K12 Scholars, monitor the progress of the Scholars, and identify opportunities for improving the program. The Scholar recruitment process will benefit from access to a large and diverse pool of internal candidates from UCSF's well-established postdoctoral training programs and provide additional opportunities for us to continue to recruit the most promising young faculty from other outstanding programs. Each Scholar will work with mentors on their career development committee to establish goals and identify didactic and hands-on training experiences to meet these goals. Scholars will have access to classes and seminars sponsored by multiple graduate programs and the UCSF Clinical and Translational Sciences Institute, and to a large assortment of omics-oriented core facilities at UCSF. K12 program activities, including a new UCSF Omics of Lung Diseases conference, will benefit Scholars who are directly support by K12 funding as well as other UCSF faculty, postdoctoral trainees, and students seeking to integrate omics approaches into pulmonary research.

Public Health Relevance

Powerful new technologies and approaches have the potential to transform our ability to understand, prevent, diagnose, and treat lung diseases. This program will provide a diverse group of Scholars with the structured mentorship, education, and hands-on training needed to master these new technologies and lead innovative lung disease research programs.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
4K12HL119997-04
Application #
9069943
Study Section
Special Emphasis Panel (ZHL1)
Program Officer
Colombini-Hatch, Sandra
Project Start
2013-09-01
Project End
2018-05-31
Budget Start
2016-06-01
Budget End
2017-05-31
Support Year
4
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118
Langelier, Charles; Zinter, Matt S; Kalantar, Katrina et al. (2018) Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients. Am J Respir Crit Care Med 197:524-528
Peters, Michael C; Ringel, Lando; Dyjack, Nathan et al. (2018) A Transcriptomic Method to Determine Airway Immune Dysfunction in T2-High and T2-Low Asthma. Am J Respir Crit Care Med :
Nardone, Anthony; Neophytou, Andreas M; Balmes, John et al. (2018) Ambient Air Pollution and Asthma-Related Outcomes in Children of Color of the USA: a Scoping Review of Literature Published Between 2013 and 2017. Curr Allergy Asthma Rep 18:29
Park, Danny S; Eskin, Itamar; Kang, Eun Yong et al. (2018) An ancestry-based approach for detecting interactions. Genet Epidemiol 42:49-63
Greenland, J R; Sun, H; Calabrese, D et al. (2017) HLA Mismatching Favoring Host-Versus-Graft NK Cell Activity Via KIR3DL1 Is Associated With Improved Outcomes Following Lung Transplantation. Am J Transplant 17:2192-2199
Hamid, U; Krasnodembskaya, A; Fitzgerald, M et al. (2017) Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS. Thorax 72:971-980
Thakur, Neeta; Barcelo, Nicolas E; Borrell, Luisa N et al. (2017) Perceived Discrimination Associated With Asthma and Related Outcomes in Minority Youth: The GALA II and SAGE II Studies. Chest 151:804-812
Christenson, Stephanie A; Steiling, Katrina (2017) Shifting from Correlation to Causation: Challenges for the Future of Unbiased Molecular Studies in Inflammatory Lung Disease. Am J Respir Crit Care Med 195:5-7
Denlinger, Loren C; Phillips, Brenda R; Ramratnam, Sima et al. (2017) Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations. Am J Respir Crit Care Med 195:302-313
Brown, Lillian; Langelier, Charles; Reid, Michael J A et al. (2017) Antimicrobial Resistance: A Call to Action! Clin Infect Dis 64:106-107

Showing the most recent 10 out of 36 publications