This training program is an extension of a program currently funded by NHLBI K12 HL089990 (""""""""Translational Genetics and Genomics of Airways Diseases""""""""). This K12 program, which has operated successfully for the past 5 years, is closely linked with our T32 HL007427 program (""""""""Clinical Epidemiology of Lung Diseases""""""""), which has been in continuous operation for 37 years. Both of these training programs focus on systems genetics and genomics of chronic respiratory diseases, particularly asthma and chronic obstructive pulmonary disease (COPD), which are major public health problems. Asthma and COPD are linked via common environmental and genetic susceptibility;these factors influence disease expression throughout life. Based on our current knowledge of complex diseases, there is a critical need for individuals trained in the application of systems and integrative genomic methods to perform quantitative research in respiratory biology. Therefore, we propose to revise and extend our current K12 training program with an increased emphasis on systems biology, network science, and multiple -omics approaches. The proposed K12 program will be instrumental in meeting the need for increased computational biology expertise in respiratory disease research by successfully training independent research investigators who will go on to lead their own research programs across the U.S.. The proposed K12 program provides research training in six major areas: (1) Systems Genetics (GWAS, Fine Mapping, and Pharmacogenetics);(2) Functional Genetics;(3) Emerging -Omics (Proteomics/Metabolomics/Microbiomics);(4) Transcriptomics, including integrative genomics;(5) Epigenomics;and (6) Systems Biology/Network Modeling. Two Scholar slots are requested in this proposal. The Scholars interact with a pool of 31 core faculty mentors in the six interrelated research areas. Each Scholar will have the opportunity to become involved in the design, execution, and analysis of ongoing federally and non-federally funded research projects, as well as develop an independent career path. Scholars'research is conducted in the Channing Division of Network Medicine, a research division of the Department of Medicine at Brigham and Women's Hospital (BWH) and Harvard Medical School (HMS). After completing our program, K12 Scholars will be eligible to assume faculty positions in systems genetics and genomics. Scholars benefit from a close relationship with the Departments of Biostatistics at the Harvard School of Public Health, the Program in Bioinformatics at Children's Hospital Boston and the Partners Center for Personalized Genetic Medicine. In the past 5 years, we have had 100% retention of K12 trainees in faculty positions and 62 % who have moved on to completely independent funding.

Public Health Relevance

Channing Division of Network Medicine Career Development Program in Systems Genetics and Genomics of Lung Diseases Providing appropriate training in respiratory genetics, genomics, systems biology, and network science will be essential for the next generation of leaders in respiratory research. This K12 mentored program will build on our successful track record of training with both formal didactic education and mentored research experiences. The medical researchers trained in this program have made, and will continue to make, important contributions to our understanding of asthma and COPD that will lead to more effective treatment for these diseases.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HL120004-02
Application #
8722621
Study Section
Special Emphasis Panel (ZHL1-CSR-J (M1))
Program Officer
Colombini-Hatch, Sandra
Project Start
2013-09-01
Project End
2018-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
2
Fiscal Year
2014
Total Cost
$269,998
Indirect Cost
$20,000
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Hayden, Lystra P; Cho, Michael H; Raby, Benjamin A et al. (2018) Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study. Respir Res 19:209
Hayden, Lystra P; Hardin, Megan E; Qiu, Weiliang et al. (2018) Asthma Is a Risk Factor for Respiratory Exacerbations Without Increased Rate of Lung Function Decline: Five-Year Follow-up in Adult Smokers From the COPDGene Study. Chest 153:368-377
Hardin, Megan; Cho, Michael H; Sharma, Sunita et al. (2017) Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. Am J Respir Cell Mol Biol 56:332-341
Dahlin, Amber; Weiss, Scott T (2016) Genetic and Epigenetic Components of Aspirin-Exacerbated Respiratory Disease. Immunol Allergy Clin North Am 36:765-789
Hardin, M; Cho, M H; McDonald, M-L et al. (2016) A genome-wide analysis of the response to inhaled ?2-agonists in chronic obstructive pulmonary disease. Pharmacogenomics J 16:326-35
Hobbs, Brian D; Parker, Margaret M; Chen, Han et al. (2016) Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 194:48-57
Hardin, Megan; Foreman, Marilyn; Dransfield, Mark T et al. (2016) Sex-specific features of emphysema among current and former smokers with COPD. Eur Respir J 47:104-12
Dahlin, A; Litonjua, A; Irvin, C G et al. (2016) Genome-wide association study of leukotriene modifier response in asthma. Pharmacogenomics J 16:151-7