The aims of this project are to correlate changes in SOD levels with a particular disease, namely ARDS and to assess the effectiveness of the SOD variants at alleviating the damage in a rat model of acute lung injury. This project will also address the mechanisms of extracellular superoxide dismutase alterations in mammalian tissue culture models of oxidative stress and identify possible markers of acute lung injury in vivo.
| Gu, Y; Wu, R F; Xu, Y C et al. (2001) HIV Tat activates c-Jun amino-terminal kinase through an oxidant-dependent mechanism. Virology 286:62-71 |
| Seve, M; Favier, A; Osman, M et al. (1999) The human immunodeficiency virus-1 Tat protein increases cell proliferation, alters sensitivity to zinc chelator-induced apoptosis, and changes Sp1 DNA binding in HeLa cells. Arch Biochem Biophys 361:165-72 |
| Vaitaitis, G M; Sanderson, R J; Kimble, E J et al. (1999) Modification of enzyme-conjugated streptavidin-biotin western blot technique to avoid detection of endogenous biotin-containing proteins. Biotechniques 26:854-8 |
