The interactions of tumor cells with the extracellular matrix found within the lymph nodes will be studied. Understanding how tumor cells invade the lymphatics and interact with the components of the extracellular matrix may explain why this tissue is such a fertile environment for tumor cell growth. This is especially relevant to head and neck cancers in which lymphatic metastasis is the primary mechanism of tumor dissemination.
The specific aims are (1) to characterize the mouse B16 melanoma model for lymphatic metastasis; (2) to examine the adhesion of metastatic cells to lymph node tissue elements; (3) to examine the role of tumor cell surface adhesion receptors in extracellular matrix interactions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Unknown (K15)
Project #
5K15DE000242-04
Application #
3088582
Study Section
NIDCR Special Grants Review Committee (DSR)
Project Start
1988-07-01
Project End
1993-06-30
Budget Start
1991-07-01
Budget End
1992-06-30
Support Year
4
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Dentistry
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143