The topic of research is the neurobiology of affiliation, one of the domains of social behavior. The candidate's previous clinical research has provided empirical support for the use of diminished social affiliative behaviors as a marker for the primary, enduring negative symptoms, or deficit syndrome, of schizophrenia. The fundamental neurobiology of social attachment and asociality has potential relevance to the asociality of schizophrenia, and is of great importance to other mental illnesses. Understanding the basic neurobiology of affiliation and asociality could lead to the rational development of pharmacological treatments. Training will consist of formal course work, directed readings, and supervised research. The research will concern the neural basis of social affiliative behaviors in the highly social rodent, Microtus ochrogaster. Site-specific lesions of the nuclear groups of the amygdala will be used to begin investigation of this circuit.
| Kirkpatrick, B; Ram, R; Amador, X F et al. (1998) Summer birth and the deficit syndrome of schizophrenia. Am J Psychiatry 155:1221-6 |
| Kirkpatrick, B; Litman, D; Kim, J W et al. (1997) Failure of fusion of the septum pellucidum and the heterogeneity of schizophrenia. J Nerv Ment Dis 185:639-41 |
| Kirkpatrick, B; Ross, D E (1997) The trap of protopathic bias in neuropsychiatric research. Biol Psychiatry 41:257-8 |
| Kirkpatrick, B; Amador, X F; Yale, S A et al. (1996) The deficit syndrome in the DSM-IV Field Trial. Part II. Depressive episodes and persecutory beliefs. Schizophr Res 20:79-90 |
| Kim, J W; Kirkpatrick, B (1996) Social isolation in animal models of relevance to neuropsychiatric disorders. Biol Psychiatry 40:918-22 |
| Kirkpatrick, B; Ram, R; Bromet, E (1996) The deficit syndrome in the Suffolk County Mental Health Project. Schizophr Res 22:119-26 |
| Kirkpatrick, B; Amador, X F; Flaum, M et al. (1996) The deficit syndrome in the DSM-IV Field Trial: I. Alcohol and other drug abuse. Schizophr Res 20:69-77 |
| Bustillo, J R; Kirkpatrick, B; Buchanan, R W (1995) Neuroleptic treatment and negative symptoms in deficit and nondeficit schizophrenia. Biol Psychiatry 38:64-7 |
| Kirkpatrick, B; Amador, X F (1995) The study of paranoia and suspiciousness. Biol Psychiatry 38:496-7 |
| Carpenter Jr, W T; Buchanan, R W; Kirkpatrick, B (1995) New diagnostic issues in schizophrenic disorders. Clin Neurosci 3:57-63 |
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