This candidate for an ADAMHA SDAC proposes an organized five year program of didactic study and supervised research that will provide her with the specific research methods she needs to become an independent investigator in pediatric neuropsychiatry. The career development plan under the preceptorship of Martha Denckla, Professor of Neurology at Johns Hopkins University, includes the supervised development of psychiatric scales for a head injured population and the attainment of facility in the use of a computerized lesion location technique. The plan includes a didactic component with laboratory courses in neuroscience, biostatistics and epidemiology. The supervised research project examines the psychopathology of severe head injury in children and adolescents. Psychiatric sequelae are among the most serious and enduring disabilities of head injured patients. The frontal lobes and their connections are convergence areas for the control of emotional and intellectual functions. This study will focus on documenting the contribution of lesion location to a spectrum of psychiatric outcomes. Specifically, the following psychiatric hypotheses will be tested: that patients with MRI frontal lobe pathology limited to the orbital frontal lobe will develop psychiatric symptoms of disinhibited behaviors; that patients with MRI frontal lobe pathology limited to the mesial frontal lobe will demonstrate symptoms of underactivated behaviors; and that either orbital or mesial frontal lobe lesions will intensify pretraumatic psychiatric symptoms. Dorsolateral frontal lesions, while neither causing nor intensifying psychiatric symptoms, will cause specific cognitive impairment.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Unknown (K20)
Project #
5K20MH000997-03
Application #
2240304
Study Section
Research Scientist Development Review Committee (MHK)
Project Start
1992-08-01
Project End
1997-07-31
Budget Start
1994-09-30
Budget End
1995-07-31
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Hugo W. Moser Research Institute Kennedy Krieger
Department
Type
DUNS #
167202410
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Vasa, Roma A; Suskauer, Stacy J; Thorn, Julia M et al. (2015) Prevalence and predictors of affective lability after paediatric traumatic brain injury. Brain Inj 29:921-8
Gerring, Joan P; Grados, Marco A; Slomine, Beth et al. (2009) Disruptive behaviour disorders and disruptive symptoms after severe paediatric traumatic brain injury. Brain Inj 23:944-55
Cole, Wesley R; Gerring, Joan P; Gray, Robert M et al. (2008) Prevalence of aggressive behaviour after severe paediatric traumatic brain injury. Brain Inj 22:932-9
Slomine, Beth S; Salorio, Cynthia F; Grados, Marco A et al. (2005) Differences in attention, executive functioning, and memory in children with and without ADHD after severe traumatic brain injury. J Int Neuropsychol Soc 11:645-53
Salorio, Cynthia F; Slomine, Beth S; Grados, Marco A et al. (2005) Neuroanatomic correlates of CVLT-C performance following pediatric traumatic brain injury. J Int Neuropsychol Soc 11:686-96
Vasa, Roma A; Grados, Marco; Slomine, Beth et al. (2004) Neuroimaging correlates of anxiety after pediatric traumatic brain injury. Biol Psychiatry 55:208-16
Slomine, Beth S; Gerring, Joan P; Grados, Marco A et al. (2002) Performance on measures of executive function following pediatric traumatic brain injury. Brain Inj 16:759-72
Vasa, Roma A; Gerring, Joan P; Grados, Marco et al. (2002) Anxiety after severe pediatric closed head injury. J Am Acad Child Adolesc Psychiatry 41:148-56
Gerring, Joan P; Slomine, Beth; Vasa, Roma A et al. (2002) Clinical predictors of posttraumatic stress disorder after closed head injury in children. J Am Acad Child Adolesc Psychiatry 41:157-65
Grados, M A; Slomine, B S; Gerring, J P et al. (2001) Depth of lesion model in children and adolescents with moderate to severe traumatic brain injury: use of SPGR MRI to predict severity and outcome. J Neurol Neurosurg Psychiatry 70:350-8

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