Abstract

My research plan is driven by the general hypothesis that genes with trinucleotide repeats (TNRs) are expressed in brain and when they under expansion, cause neuropsychiatric disease. It is known that genes containing TNRs are frequently polymorphic and are to that extent valuable as linkage markers. My research development plan builds on my present skills of linkage mapping and extends them to gene cloning and expression analysis. My long term career plans are to identify, characterize and study genes involved with psychiatric disease. I will identify and characterize cDNA clones containing TNRs and will map these repeats and examine bipolar affective disorder family members for evidence of expansion.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Unknown (K20)
Project #
5K20MH001088-05
Application #
2674363
Study Section
Biological Psychopathology Review Committee (BPP)
Program Officer
Goldschmidts, Walter L
Project Start
1994-05-01
Project End
1999-12-31
Budget Start
1998-05-15
Budget End
1999-12-31
Support Year
5
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Nwulia, Evaristus A; Miao, Kuangyi; Zandi, Peter P et al. (2007) Genome-wide scan of bipolar II disorder. Bipolar Disord 9:580-8
Lan, Tsuo-Hung; Beaty, Terri H; DePaulo, J Raymond et al. (2007) Parent-of-origin effect in the segregation analysis of bipolar affective disorder families. Psychiatr Genet 17:93-101
Swift-Scanlan, Theresa; Coughlin, Jennifer M; Lan, Tsuo-Hung et al. (2005) Characterization of CTG/CAG repeats on chromosome 18: a study of bipolar disorder. Psychiatr Genet 15:91-9
McInnis, M G; Lan, T-H; Willour, V L et al. (2003) Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12. Mol Psychiatry 8:288-98
McInnis, Melvin G; Dick, Danielle M; Willour, Virginia L et al. (2003) Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees. Biol Psychiatry 54:1265-73
Chen, H; Huo, Y; Patel, S et al. (2000) Gene identification using exon amplification on human chromosome 18q21: implications for bipolar disorder. Mol Psychiatry 5:502-9
McInnis, M G; Swift-Scanlanl, T; Mahoney, A T et al. (2000) Allelic distribution of CTG18.1 in Caucasian populations: association studies in bipolar disorder, schizophrenia, and ataxia. Mol Psychiatry 5:439-42
Breschel, T S; McInnis, M G; Margolis, R L et al. (1997) A novel, heritable, expanding CTG repeat in an intron of the SEF2-1 gene on chromosome 18q21.1. Hum Mol Genet 6:1855-63
Margolis, R L; Breschel, T S; Li, S H et al. (1995) Polymorphic (AAT) in trinucleotide repeats derived from a human brain cDNA library. Hum Genet 96:495-6