This is an application for a Scientist Development Award for Clinicians (K20) with a focus on developmental psychopathology and the addictive disorders. Despite the high rates of the psychoactive substance use disorders (PSUD) in the population, little is known about the development of these disorders in children and adolescents. Previous studies indicate dysfunction in multiple domains in children and adolescents who develop PSUD, or are at risk to develop PSUD by nature of having a parent with PSUD. However, there are a paucity of studies identifying specific psychopathologic, addictive, psychosocial, and cognitive disorders in the children of PSUD parents. Similarly, despite high rates of comorbid disorders in PSUD parents, family-genetic analyses assessing the role of other parental disorders on their children are lacking. During the period of the Award, the candidate proposes to undertake comprehensive assessments of parents with PSUD and their children aged 2 to 17 years, and compare findings to non-PSUD control families. This proposed investigation will be based at the Massachusetts General Hospital in collaboration with two community' drug and alcohol treatment sites (alcohol and opioid dependent parents).

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Unknown (K20)
Project #
5K20MH001175-05
Application #
2674384
Study Section
Child/Adolescent Risk and Prevention Review Committee (CAPR)
Project Start
1994-05-01
Project End
1999-04-30
Budget Start
1998-05-01
Budget End
1999-04-30
Support Year
5
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Wilens, T E; Biederman, J; Wong, J et al. (2000) Adjunctive donepezil in attention deficit hyperactivity disorder youth: case series. J Child Adolesc Psychopharmacol 10:217-22
Wilens, T E; Biederman, J; Spencer, T J et al. (1999) A pilot controlled clinical trial of ABT-418, a cholinergic agonist, in the treatment of adults with attention deficit hyperactivity disorder. Am J Psychiatry 156:1931-7
Wilens, T E; Biederman, J; Mick, E (1998) Does ADHD affect the course of substance abuse? Findings from a sample of adults with and without ADHD. Am J Addict 7:156-63
Biederman, J; Wilens, T E; Mick, E et al. (1998) Does attention-deficit hyperactivity disorder impact the developmental course of drug and alcohol abuse and dependence? Biol Psychiatry 44:269-73
Wilens, T E; Biederman, J; Spencer, T J (1997) Case study: adverse effects of smoking marijuana while receiving tricyclic antidepressants. J Am Acad Child Adolesc Psychiatry 36:45-8
Wilens, T E; Biederman, J; Mick, E et al. (1997) Attention deficit hyperactivity disorder (ADHD) is associated with early onset substance use disorders. J Nerv Ment Dis 185:475-82
Wilens, T E; Biederman, J; Baldessarini, R J et al. (1996) Cardiovascular effects of therapeutic doses of tricyclic antidepressants in children and adolescents. J Am Acad Child Adolesc Psychiatry 35:1491-501
Biederman, J; Wilens, T; Mick, E et al. (1995) Psychoactive substance use disorders in adults with attention deficit hyperactivity disorder (ADHD): effects of ADHD and psychiatric comorbidity. Am J Psychiatry 152:1652-8