Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Scientist Development Award (K21)
Project #
5K21MH001237-02
Application #
2032841
Study Section
Neuropharmacology and Neurochemistry Review Committee (NPNC)
Project Start
1995-09-15
Project End
2000-04-30
Budget Start
1996-09-15
Budget End
1997-04-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Tufts University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02111
Venkatakrishnan, K; von Moltke, L L; Greenblatt, D J (2001) Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate. J Pharmacol Exp Ther 297:326-37
Hesse, L M; Venkatakrishnan, K; Court, M H et al. (2000) CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants. Drug Metab Dispos 28:1176-83
Greenblatt, D J; von Moltke, L L; Harmatz, J S et al. (1999) Human cytochromes mediating sertraline biotransformation: seeking attribution. J Clin Psychopharmacol 19:489-93
Greenblatt, D J; Wright, C E; von Moltke, L L et al. (1998) Ketoconazole inhibition of triazolam and alprazolam clearance: differential kinetic and dynamic consequences. Clin Pharmacol Ther 64:237-47
Greenblatt, D J; Harmatz, J S; von Moltke, L L et al. (1998) Comparative kinetics and dynamics of zaleplon, zolpidem, and placebo. Clin Pharmacol Ther 64:553-61
Schmider, J; Greenblatt, D J; Fogelman, S M et al. (1997) Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1. Biopharm Drug Dispos 18:227-40
Schmider, J; Greenblatt, D J; von Moltke, L L et al. (1997) Biotransformation of mestranol to ethinyl estradiol in vitro: the role of cytochrome P-450 2C9 and metabolic inhibitors. J Clin Pharmacol 37:193-200
Charpentier, K P; von Moltke, L L; Poku, J W et al. (1997) Alprazolam hydroxylation by mouse liver microsomes in vitro: the effect of age and phenobarbital induction. Biopharm Drug Dispos 18:139-49
Schmider, J; Greenblatt, D J; von Moltke, L L et al. (1997) Inhibition of CYP2C9 by selective serotonin reuptake inhibitors in vitro: studies of phenytoin p-hydroxylation. Br J Clin Pharmacol 44:495-8
Schmider, J; Greenblatt, D J; von Moltke, L L et al. (1996) Inhibition of cytochrome P450 by nefazodone in vitro: studies of dextromethorphan O- and N-demethylation. Br J Clin Pharmacol 41:339-43

Showing the most recent 10 out of 12 publications