Over 90% of the 211,300 women diagnosed with breast cancer in 2003 will undergo surgery as part of their curative treatment. Despite improvements in pharmacological management, surgical procedures under general anesthesia continue to be associated with clinically significant side effects, chief among which are pain and nausea. These clinical problems are particularly severe following surgical treatment for breast cancer and can require additional pharmacologic intervention, prolong recovery room stay, delay discharge, and lead to unanticipated readmission. Clinical research with other patient populations has indicated that presurgery hypnosis reduces intraoperative complications, postoperative symptoms, and enhances recovery. Preliminary data with breast surgery patients has revealed that a brief presurgery hypnosis with a psychologist can significantly improve post-surgery recovery relative to an attention control condition. Yet to be formally examined is the need for a """"""""live"""""""" intervention by a professional: a critical question before translation to everyday clinical practice can be accomplished. Furthermore, the intervention may have long term """"""""side benefits."""""""" The study goal is to establish the relative efficacy and cost of """"""""live"""""""" and recorded presurgical hypnosis interventions in mastectomy patients. Study innovations include investigation of the effects of moderators and mediators on the differential group effects, as well as an exploration of the side benefits of the intervention for 12 months following surgery. The results of this original research proposal will speak to both clinical application and scientific understanding.
The Specific Aims, are to: 1) Investigate the beneficial impact of """"""""live"""""""" and recorded presurgical hypnosis interventions in women scheduled for breast cancer surgery; 2) Examine the effects of potential moderating variables of the hypnosis interventions on post-surgery side effects and recovery; 3) Determine whether the beneficial effects of the hypnosis intervention are accounted for (mediated) by differences in presurgery cognitive expectations and emotional distress; and 4) Investigate the possibility that the hypnosis intervention has side benefits for women facing breast cancer and its treatment. To achieve these Aims, 125 breast cancer mastectomy patients will be randomly assigned to 5 Groups. Groups differ on Surgery Day intervention (3 levels: """"""""live"""""""" hypnosis session; recorded hypnosis session; control) and Hypnosis Practice Period (2 levels: Yes; No - Controls exempted) to determine the relative contributions of """"""""live,"""""""" recorded, and practice period presurgery hypnosis to reducing side effects and enhancing recovery. The design allows direct comparisons of both clinical impact and cost effectiveness of these interventions in a randomized clinical trial. Mediators and moderators (e.g., hypnotizability) of hypnosis effects will be determined, as well as long-term side benefits of the intervention.
| Wright, Caroline E; Schnur, Julie B; Montgomery, Guy H et al. (2010) Psychological factors associated with poor sleep prior to breast surgery: an exploratory study. Behav Med 36:85-91 |
| Schnur, Julie B; David, Daniel; Kangas, Maria et al. (2009) A randomized trial of a cognitive-behavioral therapy and hypnosis intervention on positive and negative affect during breast cancer radiotherapy. J Clin Psychol 65:443-55 |
| Wright, Caroline E; Bovbjerg, Dana H; Montgomery, Guy H et al. (2009) Disrupted sleep the night before breast surgery is associated with increased postoperative pain. J Pain Symptom Manage 37:352-62 |
| Schnur, Julie B; Montgomery, Guy H (2008) Hypnosis and cognitive-behavioral therapy during breast cancer radiotherapy: a case report. Am J Clin Hypn 50:209-15 |
| Schnur, Julie B; Bovbjerg, Dana H; David, Daniel et al. (2008) Hypnosis decreases presurgical distress in excisional breast biopsy patients. Anesth Analg 106:440-4, table of contents |
| Kirsch, Irving; Mazzoni, Giuliana; Montgomery, Guy H (2007) Hypnotic history: a reply to critics. Am J Clin Hypn 49:249-54 |
| Higgins, Sara C; Montgomery, Guy H; Bovbjerg, Dana H (2007) Distress before chemotherapy predicts delayed but not acute nausea. Support Care Cancer 15:171-7 |
| Kirsch, Irving; Mazzoni, Giuliana; Montgomery, Guy H (2007) Remembrance of hypnosis past. Am J Clin Hypn 49:171-8;discussion 179-80, 183-4 |
| Schnur, Julie B; Hallquist, Michael N; Bovbjerg, Dana H et al. (2007) Predictors of expectancies for post-surgical pain and fatigue in breast cancer surgical patients. Pers Individ Dif 42:419-429 |
| Montgomery, Guy H; Bovbjerg, Dana H; Schnur, Julie B et al. (2007) A randomized clinical trial of a brief hypnosis intervention to control side effects in breast surgery patients. J Natl Cancer Inst 99:1304-12 |
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