Dr. Matthew Freiberg is a clinical instructor in the General Internal Medicine Section at the Boston University School of Medicine and research collaborator at the Framingham Heart Study who seeks a Mentored Patient-Oriented Research Career Development Award (K23) in order to transition to an independent clinician investigator. This proposal focuses on the association of alcohol to coronary heart disease (CHD) in adults with HIV. In adults without HIV, the association between alcohol and CHD is """"""""J"""""""" shaped, with heavy drinkers at the highest risk, abstainers at intermediate risk, and moderate drinkers at the lowest risk. With improved survival of adults with HIV, CHD is now prevalent in this population, however, the risk of CHD associated with alcohol in adults with HIV is not known. As alcohol use is common in adults with HIV, Dr. Freiberg will test the following hypothesis by pursing three specific aims: In adults with HIV the association between alcohol and CHD risk is """"""""J"""""""" shaped.
Aim #1 will evaluate the cross-sectional association between alcohol and CHD risk using the Framingham Risk Score, a validated composite measure of CHD risk.
Aim #2 will evaluate the cross-sectional association between alcohol and prevalent CHD using multivariable logistic regression.
Aim#3 will prospectively evaluate the association between alcohol and CHD mortality using proportional hazards models.
Aims #1 & 2 will be addressed by studying the HIV LIVE (Longitudinal Interrelationships of Viruses and Ethanol Study) and Veterans Aging Cohort Study (VACS) cohorts.
Aim #3 will be addressed using the Virtual VACS with the 1999 Large Health Survey of Veteran Enrollees. Together, these cohorts provide detailed data on alcohol use, CHD risk factors, CHD, and mortality. Experts in the fields of moderate and heavy alcohol consumption, HIV and HIV-related co-morbidities, alcohol problems in HIV, and CHD epidemiology will supervise Dr. Freiberg's career development. He will receive (1) specific training in advanced epidemiologic and statistical techniques at the Boston University School of Public Health and the Framingham Heart Study and (2) the skills necessary to initiate and maintain an active cohort of alcohol affected study participants. As alcohol consumption and CHD are two important health issues facing adults with HIV, understanding the risks of CHD associated with alcohol will be important to expert panels creating consumption guidelines and health professionals who advise patients with HIV.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
7K23AA015914-02
Application #
7243987
Study Section
AIDS Clinical Studies and Epidemiology Study Section (ACE)
Program Officer
Roach, Deidra
Project Start
2005-09-30
Project End
2010-08-31
Budget Start
2006-06-12
Budget End
2006-08-31
Support Year
2
Fiscal Year
2005
Total Cost
$164,497
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Armah, Kaku A; McGinnis, Kathleen; Baker, Jason et al. (2012) HIV status, burden of comorbid disease, and biomarkers of inflammation, altered coagulation, and monocyte activation. Clin Infect Dis 55:126-36
Freiberg, Matthew S; Chang, Chung-Chou H; Skanderson, Melissa et al. (2011) The risk of incident coronary heart disease among veterans with and without HIV and hepatitis C. Circ Cardiovasc Qual Outcomes 4:425-32
Freiberg, Matthew S; McGinnis, Kathleen A; Kraemer, Kevin et al. (2010) The association between alcohol consumption and prevalent cardiovascular diseases among HIV-infected and HIV-uninfected men. J Acquir Immune Defic Syndr 53:247-53
Freiberg, Matthew S; Leaf, David A; Goulet, Joseph L et al. (2009) The association between the receipt of lipid lowering therapy and HIV status among veterans who met NCEP/ATP III criteria for the receipt of lipid lowering medication. J Gen Intern Med 24:334-40
Freiberg, Matthew S; Chang, Yue-Fang; Kraemer, Kevin L et al. (2009) Alcohol consumption, hypertension, and total mortality among women. Am J Hypertens 22:1212-8
Freiberg, Matthew S; Pencina, Michael J; D'Agostino, Ralph B et al. (2008) BMI vs. waist circumference for identifying vascular risk. Obesity (Silver Spring) 16:463-9
Freiberg, Matthew S; Arnold, Alice M; Newman, Anne B et al. (2008) Abdominal aortic aneurysms, increasing infrarenal aortic diameter, and risk of total mortality and incident cardiovascular disease events: 10-year follow-up data from the Cardiovascular Health Study. Circulation 117:1010-7
Freiberg, Matthew S; Cheng, Debbie M; Kraemer, Kevin L et al. (2007) The association between hepatitis C infection and prevalent cardiovascular disease among HIV-infected individuals. AIDS 21:193-7