Limitations in mobility affect almost one in 4 individuals over 65 and have been demonstrated to be predictive of disability and institutionalization. In those most limited, muscular power, the ability to perform muscular work per unit time, is closely associated with the functional tasks that predict disability. Muscular power is a separate attribute from strength declining more precipitously in late life. The preservation of muscular power in late life has been recently identified as high priority for gerontological research. The candidate in this application is a physiatrist, a clinician researcher with a Masters in Exercise Physiology, who specializes in geriatric rehabilitation. It is the applicant's goal to evaluate the influence of eight Vest Exercise a form of muscle power training (MPT) on functional loss in mobility limited elders. Through pilot studies in elders with mobility limitations, the applicant and his collaborators have demonstrated the close relationship between lower extremity muscular power and important tasks of functional performance. Additionally, pilot studies have shown that MPT is not only safe, but also more potent than strength training at correcting lower extremity motor impairments. Lastly, the applicant is investigating the potential of Weighted Vest Exercise, having preliminary results demonstrating its effectiveness. This award is framed around the following activities: 1) conducting a pilot intervention trial utilizing weighted vest exercise, a potential home-based type of MPT in elders with significant mobility limitations; 2) enhance my career development plan through continued involvement as co-investigator in an RO1 studying closely related issues; 3) completing studies in clinical trial methodology and utilizing these previous experiences as the basis for a randomized controlled trial, that is appropriately powered to evaluate the influence of non-machine based MPT on all disablement outcomes, including disability; and 4) develop the skills, expertise and experience to become a successful independent clinician scientist within the field of geriatric rehabilitation. This proposal contains a strong environment and mentorship plan containing leading institutions and individuals from the fields of Aging and Rehabilitation. It will provide important insights into exercise's role in preserving late life functioning.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23AG019663-02
Application #
6804717
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Yancik, Rosemary
Project Start
2003-09-30
Project End
2007-08-31
Budget Start
2004-09-01
Budget End
2005-08-31
Support Year
2
Fiscal Year
2004
Total Cost
$156,870
Indirect Cost
Name
Spaulding Rehabilitation Hospital
Department
Type
DUNS #
079520862
City
Boston
State
MA
Country
United States
Zip Code
02129
Bean, Jonathan F; Beauchamp, Marla K; Ni, Meng (2016) Targeted Exercise Training to Optimize Leg Power, Leg Speed, and Mobility in Older Adults. J Am Geriatr Soc 64:2608-2609
Pardasaney, Poonam K; Ni, Pengsheng; Slavin, Mary D et al. (2014) Computer-adaptive balance testing improves discrimination between community-dwelling elderly fallers and nonfallers. Arch Phys Med Rehabil 95:1320-1327.e1
Beauchamp, Marla K; Leveille, Suzanne G; Patel, Kushang V et al. (2014) What physical attributes underlie self-reported vs. observed ability to walk 400 m in later life? An analysis from the InCHIANTI Study. Am J Phys Med Rehabil 93:396-404
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Pardasaney, Poonam K; Latham, Nancy K; Jette, Alan M et al. (2012) Sensitivity to change and responsiveness of four balance measures for community-dwelling older adults. Phys Ther 92:388-97
Suri, Pradeep; Kiely, Dan K; Leveille, Suzanne G et al. (2011) Increased trunk extension endurance is associated with meaningful improvement in balance among older adults with mobility problems. Arch Phys Med Rehabil 92:1038-43
Bean, Jonathan F; Olveczky, Daniele D; Kiely, Dan K et al. (2011) Performance-based versus patient-reported physical function: what are the underlying predictors? Phys Ther 91:1804-11
Bean, Jonathan F; Kiely, Dan K; LaRose, Sharon et al. (2010) Are changes in leg power responsible for clinically meaningful improvements in mobility in older adults? J Am Geriatr Soc 58:2363-8
Suri, Pradeep; Kiely, Dan K; Leveille, Suzanne G et al. (2009) Trunk muscle attributes are associated with balance and mobility in older adults: a pilot study. PM R 1:916-24
Bean, Jonathan F; Kiely, Dan K; LaRose, Sharon et al. (2009) Increased velocity exercise specific to task training versus the National Institute on Aging's strength training program: changes in limb power and mobility. J Gerontol A Biol Sci Med Sci 64:983-91

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