This Paul B. Beeson Career Development Award in Aging application is designed to further the candidate's development as an independent investigator in patient-oriented geriatric research. The career development plan builds directly on the candidate's previous training in Medicine, Neurology, Neurophysiology, and Epidemiology. The three-year career development plan emphasizes four areas: 1) longitudinal quantitative methods and analysis, 2) translational biological research, 3) gait/mobility, and 4) bioethics. Five different learning modalities are emphasized: a) formal coursework, b) reading tutorials, c) research colloquia and seminars, d) on and off-site practical with mentors, and e) supervised research proposal. Over one-third of adults over age 65 report at least one severe disability. The disablement process describes a continuum leading from disease to impairments, to functional limitations, and ultimately disability. Clinical and biological markers of the earliest stages of this process are lacking, especially in high functioning older adults. Physical and cognitive stress tests may reveal latent mobility abnormalities in high functioning older adults with low physiological reserves. The research focus of this application is to identify latent mobility abnormalities and their biological basis in non-disabled older adults. Specifically, we will 1) Examine the role of latent mobility abnormalities in response to physical and cognitive stressors as predictors of disability. 2) Determine the relationship between latent mobility abnormalities and inflammatory biomarkers. To achieve these aims, 300 non-disabled older adults will be assessed with comprehensive qualitative and quantitative mobility assessments at 6-monthly intervals over five years. Identifying latent mobility abnormalities will allow introduction of specific interventions early in the disablement process. The career development activities in this application will enable the candidate to be an independent investigator in aging, a clinical expert in cognitive and physical disability, and a mentor for the next generation of investigators. ? ?
| Verghese, Joe; Wang, Cuiling; Lipton, Richard B et al. (2013) Motoric cognitive risk syndrome and the risk of dementia. J Gerontol A Biol Sci Med Sci 68:412-8 |
| Verghese, Joe; Holtzer, Roee (2010) Walking the walk while talking: cognitive therapy for mobility in dementia? Neurology 74:1938-9 |
| Verghese, Joe; Robbins, Matthew; Holtzer, Roee et al. (2008) Gait dysfunction in mild cognitive impairment syndromes. J Am Geriatr Soc 56:1244-51 |
| Verghese, Joe; Wang, Cuiling; Xue, Xiaonan et al. (2008) Self-reported difficulty in climbing up or down stairs in nondisabled elderly. Arch Phys Med Rehabil 89:100-4 |
| Verghese, Joe; Wang, Cuiling; Lipton, Richard B et al. (2007) Quantitative gait dysfunction and risk of cognitive decline and dementia. J Neurol Neurosurg Psychiatry 78:929-35 |
| Verghese, J; Derby, C; Katz, M J et al. (2007) High risk neurological gait syndrome and vascular dementia. J Neural Transm 114:1249-52 |
| Verghese, Joe; Kuslansky, Gail; Holtzer, Roee et al. (2007) Walking while talking: effect of task prioritization in the elderly. Arch Phys Med Rehabil 88:50-3 |
| Holtzer, Roee; Friedman, Rachel; Lipton, Richard B et al. (2007) The relationship between specific cognitive functions and falls in aging. Neuropsychology 21:540-8 |
| Verghese, Joe; LeValley, Aaron; Hall, Charles B et al. (2006) Epidemiology of gait disorders in community-residing older adults. J Am Geriatr Soc 54:255-61 |
| Verghese, J; LeValley, A; Derby, C et al. (2006) Leisure activities and the risk of amnestic mild cognitive impairment in the elderly. Neurology 66:821-7 |
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