Global malaria control is threatened by antimalarial drug resistance. New antimalarial therapies and a better understanding of the mechanisms of drug resistance are urgently needed. The overall goals of this project are to evaluate the efficacy of alternative therapies for uncomplicated falciparum malaria in a setting of high chloroquine resistance and to study the epidemiology of malaria using molecular techniques.
The specific aims of this project are: 1) to compare the efficacy of combinations of antimalarial drugs with a standard monotherapy regimen for the treatment of uncomplicated falciparum malaria in Kampala, Uganda; 2) to distinguish recrudescence from new infections after antimalarial treatment by molecularly """"""""fingerprinting"""""""" strains of P. falciparum; and 3) to characterize the molecular basis of resistance to common antimalarial therapies. Ultimately, this investigation of falciparum malaria in Uganda will provide relevant information applicable to the formulation of drug treatment and malaria control policies and will contribute to our understanding of antimalarial drug resistance. The candidate is an infectious disease clinician with a career interest in international health. The career development plan detailed in this proposal will integrate her prior experiences with new expertise in the epidemiology of drug resistant malaria and provide a solid foundation for research and a career in academic medicine. The intellectual environment at the University of California, San Francisco and the collaboration between UCSF, Makerere University in Kampala, Uganda and the University of California, Berkeley, School of Public Health afford the candidate an opportunity to pursue her career development plan.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23AI049212-05
Application #
6917239
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Coyne, Philip Edward
Project Start
2001-07-01
Project End
2006-07-31
Budget Start
2005-07-01
Budget End
2006-07-31
Support Year
5
Fiscal Year
2005
Total Cost
$121,770
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Gantt, Soren; Huang, Meei-Li; Magaret, Amalia et al. (2013) An artesunate-containing antimalarial treatment regimen did not suppress cytomegalovirus viremia. J Clin Virol 58:276-8
Staedke, Sarah G; Jagannathan, Prasanna; Yeka, Adoke et al. (2008) Monitoring antimalarial safety and tolerability in clinical trials: a case study from Uganda. Malar J 7:107
Staedke, Sarah G; Mpimbaza, Arthur; Kamya, Moses R et al. (2004) Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial. Lancet 364:1950-7