Candidate: Dr. Kevin Fontaine, Assistant Professor of Medicine at Johns Hopkins University, who trained in Psychology at the Victoria University of Manchester, U.K., is seeking this Mentored Patient-Oriented Research Career Development Award (K23). In this revised application, he proposes a 3-year award period to complete advanced coursework and training in clinical trial design, biostatistics and research ethics, and to conduct a mentored research project to evaluate the effects of a new way to promote increased physical activity on patient oriented and disease outcomes in Rheumatoid Arthritis (RA). Project Rationale: RA is a chronic, systemic inflammatory disease that imposes a significant burden on the individual and the health care system. Although there have been advances in treating RA, it still compromises functional capacity and general health. Regular exercise improves function, disease activity, and general health in RA. Despite these benefits, most do not exercise. Thus, finding new ways to promote physical activity in patients with RA is important. Studies show that accumulating short bouts of moderate-intensity lifestyle physical activity (LPA) produces comparable health benefits to those obtained with conventional exercise. It is not known, however, whether LPA will produce benefits on functional capacity, disease activity, and general health in patients with RA. Design: The primary purpose of the mentored research proposed in this K23 application is to test the hypothesis that lifestyle physical activity (LPA) will produce benefits in patients with RA. To accomplish this, 104 adults with RA will be randomized to either a 16-week program of: 1) lifestyle physical activity (LPA); or 2) conventional exercise (CE). The primary outcome will be functional capacity. Secondary outcomes include disease activity, physical activity, fitness, and cardiovascular risk factors. The combination of education, training, and mentored clinical research in the supportive context of the Johns Hopkins University, one of the premier sites for mentored research in the country, will give Dr. Fontaine the skills and experience he needs to develop into an independent patient-oriented clinical researcher.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
1K23AR049720-01A1
Application #
6731762
Study Section
Special Emphasis Panel (ZAR1-TAS-F (O1))
Program Officer
Serrate-Sztein, Susana
Project Start
2004-04-12
Project End
2007-03-31
Budget Start
2004-04-12
Budget End
2005-03-31
Support Year
1
Fiscal Year
2004
Total Cost
$109,473
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Keith, S W; Fontaine, K R; Pajewski, N M et al. (2011) Use of self-reported height and weight biases the body mass index-mortality association. Int J Obes (Lond) 35:401-8
Keith, Scott W; Wang, Chenxi; Fontaine, Kevin R et al. (2008) BMI and headache among women: results from 11 epidemiologic datasets. Obesity (Silver Spring) 16:377-83
Heo, Moonseong; Murphy, Christopher F; Fontaine, Kevin R et al. (2008) Population projection of US adults with lifetime experience of depressive disorder by age and sex from year 2005 to 2050. Int J Geriatr Psychiatry 23:1266-70
Fontaine, Kevin R; Haaz, Steffany; Bartlett, Susan J (2007) Are overweight and obese adults with arthritis being advised to lose weight? J Clin Rheumatol 13:12-5
Fontaine, Kevin R; Haaz, Steffany; Heo, Moonseong (2007) Projected prevalence of US adults with self-reported doctor-diagnosed arthritis, 2005 to 2050. Clin Rheumatol 26:772-4
Haaz, S; Fontaine, K R; Cutter, G et al. (2006) Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update. Obes Rev 7:79-88
Fontaine, K R; Heo, M; Allison, D B (2005) Obesity and prostate cancer screening in the USA. Public Health 119:694-8
Fontaine, Kevin R; Bartlett, Susan J; Heo, Moonseong (2005) Are health care professionals advising adults with arthritis to become more physically active? Arthritis Rheum 53:279-83
Fontaine, Kevin R; Heo, Moonseong (2005) Changes in the prevalence of US adults with arthritis who meet physical activity recommendations, 2001-2003. J Clin Rheumatol 11:13-6