Psoriasis is a common chronic immune mediated disease. There is increasing evidence demonstrating that psoriasis patients have an increased risk of lymphoproliferative malignancies. The evolving therapies for psoriasis target the immune system and therefore, these treatments may further increase the rate of lymphoma in psoriasis patients. To study lymphoma outcomes in psoriasis patients a large cohort of patients needs to be followed for many years. This proposal will rigorously investigate the validity of the General Practice Research Database (GPRD), a medical record database in the United Kingdom with 9 million patients and over 35 million person years of follow up, for performing high quality population based epidemiology studies in psoriasis patients.
This aim will help develop an extremely useful tool for conducting population based studies in psoriasis patients. We will then perform a large cohort study in the GPRD population to determine if psoriasis is associated with an increased risk of lymphoma.
This aim will have important implications for monitoring the safety of immunosuppressive therapies in psoriasis patients. Finally, we will develop additional methodologies for assessing the extent of psoriasis skin involvement to determine the impact this variable has on lymphoma and other outcomes for use in studies of psoriasis in the population at large.
This aim will provide a rigorously validated method for classifying severity of psoriasis for use in a variety of future psoriasis studies. A second major goal of this application is to provide the mentoring and additional training necessary for the candidate to become an independent investigator. The candidate has established mentoring relationships with leading senior investigators that will be fostered through the studies planned in this application. The candidate will also pursue additional formal training in advanced level graduate courses in epidemiology in order to allow him build upon the foundation of expertise he has built through his previous training in epidemiology at the masters level. Through the combination of the research program, mentoring program, and additional coursework outlined in this application the candidate will be well prepared to be an independent investigator concentrating on improving the lives of patients suffering with dermatologic disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23AR051125-05
Application #
7391815
Study Section
Special Emphasis Panel (ZAR1-RJB-F (J1))
Program Officer
Baker, Carl
Project Start
2004-04-01
Project End
2009-03-31
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
5
Fiscal Year
2008
Total Cost
$132,462
Indirect Cost
Name
University of Pennsylvania
Department
Dermatology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Dommasch, Erica D; Abuabara, Katrina; Shin, Daniel B et al. (2011) The risk of infection and malignancy with tumor necrosis factor antagonists in adults with psoriatic disease: a systematic review and meta-analysis of randomized controlled trials. J Am Acad Dermatol 64:1035-50
Dommasch, E D; Shin, D B; Troxel, A B et al. (2010) Reliability, validity and responsiveness to change of the Patient Report of Extent of Psoriasis Involvement (PREPI) for measuring body surface area affected by psoriasis. Br J Dermatol 162:835-42
Mehta, Nehal N; Azfar, Rahat S; Shin, Daniel B et al. (2010) Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the General Practice Research Database. Eur Heart J 31:1000-6
Seminara, Nicole M; Gelfand, Joel M (2010) Assessing long-term drug safety: lessons (re) learned from raptiva. Semin Cutan Med Surg 29:16-9
Abuabara, K; Azfar, R S; Shin, D B et al. (2010) Cause-specific mortality in patients with severe psoriasis: a population-based cohort study in the U.K. Br J Dermatol 163:586-92
Kurd, Shanu Kohli; Troxel, Andrea B; Crits-Christoph, Paul et al. (2010) The risk of depression, anxiety, and suicidality in patients with psoriasis: a population-based cohort study. Arch Dermatol 146:891-5
Jambusaria-Pahlajani, Anokhi; Schmults, Chrysalyne D; Miller, Christopher J et al. (2009) Test characteristics of high-resolution ultrasound in the preoperative assessment of margins of basal cell and squamous cell carcinoma in patients undergoing Mohs micrographic surgery. Dermatol Surg 35:9-15; discussion 15-6
Dommasch, Erica; Gelfand, Joel M (2009) Is there truly a risk of lymphoma from biologic therapies? Dermatol Ther 22:418-30
Lee, Robert A; Dommasch, Erica; Treat, James et al. (2009) A prospective clinical trial of open-label etanercept for the treatment of hidradenitis suppurativa. J Am Acad Dermatol 60:565-73
Kurd, Shanu Kohli; Gelfand, Joel M (2009) The prevalence of previously diagnosed and undiagnosed psoriasis in US adults: results from NHANES 2003-2004. J Am Acad Dermatol 60:218-24

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