This Mentored Patient-Oriented Research Career Development Award will enable Dr. Christopher-Stine to acquire the vital methodologic skills and expertise to become an independent clinical investigator, focusing on the idiopathic inflammatory myopathies (IIM). The PI will combine her growing research experience and continued training in public health with the mentorship of Drs. Allan Gelber, Antony Rosen, and Paul Plotz. IIM, including dermatomyositis, polymyositis, and inclusion body myositis, constitute the largest subset of acquired myopathies and often affect adults in their prime. A major limitation of prior studies is the poor specificity of the diagnostic criteria used to classify IIM. The therapeutic implication for such misclassified patients is substantial. Thus, it is crucial to sharpen conventional classification criteria so that therapy is used appropriately. The published literature in IIM is also characterized by few formal prospective myositis cohort studies, yielding sparse evidence by which to reliably predict meaningful outcomes. To address and to overcome these important methodologic limitations in IIM, Dr. Christopher-Stine will interrogate the valuable NIH Protocol entitled """"""""Studies in Natural History and Pathogenesis of Polymyositis and Dermatomyositis and Related Diseases."""""""" An Associate Investigator to this protocol, Dr. Christopher-Stine has participated in patient evaluations and is currently formally organizing the demographic, clinical, serologic, and radiographic data collected on 672 patients enrolled in the protocol since 1991. To date, no formal epidemiologic database has been established using this resource. This application proposes to access, organize and establish this protocol into a systematic relational database which will be utilized to address the following Specific Aims: (1) To determine the sensitivity and specificity of Magnetic Resonance Imaging (MRI) to discriminate among IIM, muscular dystrophy, and normal muscle;(2) To determine the diagnostic value of novel genetic expression profiling among patients presenting with a myositis phenotype who remain undiagnosed after utilizing conventional diagnostic classification schema;(3) To define longitudinal predictors of mortality, disability, and malignancy. With support from this award, the invaluable complementary mentorship skills, and the expertise of the listed collaborators, Dr. Christopher-Stine is poised to develop and launch her independent clinical research career.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
Application #
Study Section
Special Emphasis Panel (ZAR1-EHB-J (02))
Program Officer
Witter, James
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Johns Hopkins University
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Park, Jin Kyun; Gelber, Allan C; George, Michael et al. (2013) Pulmonary impairment, not muscle injury, is associated with elevated ESR in the idiopathic inflammatory myopathies. Rheumatology (Oxford) 52:1336-8
Werner, Jessie L; Christopher-Stine, Lisa; Ghazarian, Sharon R et al. (2012) Antibody levels correlate with creatine kinase levels and strength in anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase-associated autoimmune myopathy. Arthritis Rheum 64:4087-93
Casciola-Rosen, Livia; Hall, John C; Mammen, Andrew L et al. (2012) Isolated elevation of aldolase in the serum of myositis patients: a potential biomarker of damaged early regenerating muscle cells. Clin Exp Rheumatol 30:548-53
Albayda, Jemima; Christopher-Stine, Lisa (2012) Novel approaches in the treatment of myositis and myopathies. Ther Adv Musculoskelet Dis 4:369-77
Khan, Sabiha; Christopher-Stine, Lisa (2011) Polymyositis, dermatomyositis, and autoimmune necrotizing myopathy: clinical features. Rheum Dis Clin North Am 37:143-58, v
Mammen, Andrew L; Chung, Tae; Christopher-Stine, Lisa et al. (2011) Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy. Arthritis Rheum 63:713-21
Saketkoo, Lesley Ann; Ascherman, Dana P; Cottin, Vincent et al. (2010) Interstitial Lung Disease in Idiopathic Inflammatory Myopathy. Curr Rheumatol Rev 6:108-119
Valiyil, Ritu; Christopher-Stine, Lisa (2010) Drug-related myopathies of which the clinician should be aware. Curr Rheumatol Rep 12:213-20
Christopher-Stine, Lisa; Casciola-Rosen, Livia A; Hong, Grace et al. (2010) A novel autoantibody recognizing 200-kd and 100-kd proteins is associated with an immune-mediated necrotizing myopathy. Arthritis Rheum 62:2757-66
Christopher-Stine, Lisa (2010) Neurologists are from Mars. Rheumatologists are from Venus: differences in approach to classifying the idiopathic inflammatory myopathies. Curr Opin Rheumatol 22:623-6

Showing the most recent 10 out of 12 publications