Psoriatic arthritis (PsA) is a chronic, debilitating inflammatory arthritis associated with psoriasis. Most studies to date include only patients with long standing disease. We know from rheumatoid arthritis, another type of inflammatory arthritis, that early identification and treatment initiation improves response to therapy and decreases joint damage and disability. It is possible that this is also the case in PsA, but to date, PsA is very difficult to identify early in the course of disease. Furthermore, very little is known about he earliest phases of PsA. As the majority of patients with PsA first develop psoriasis, patients with psoriasis represent an ideal population for studies investigating the development of PsA. In this application, we propose two approaches to detecting early disease: 1) to identify risk factors for development of PsA among patients with psoriasis, and 2) to identify subclinical articular and periarticular inflammation in patients with psoriasis, possibly the earliest form of the disease, using 18F-Flurorodeoxyglucose Positron Emission Tomography/Computed Tomography and musculoskeletal ultrasound. Not only will these studies address two potential approaches for identifying early disease, but through these innovative investigations we will gain insight into th natural history and pathophysiology of PsA development. The candidate is a rheumatologist and clinical investigator with an interest in inflammatory arthritis, particularly psoriatic arthriis, with a scientific background ideally suited for the K23 mentored career development award. Her goal is to become a successful, independently funded clinical investigator. Through the outlined career development plan and the proposed research, Dr. Ogdie will gain the required skills to achieve independence and to address her long-term objectives. The University of Pennsylvania is the ideal environment in which to conduct the proposed studies. Dr. Ogdie will leverage two existing R01 funded studies directed by the co-mentor to address the research Aims. With tremendous resources in rheumatology, dermatology, epidemiology, and radiology as well as outstanding mentorship, facilities, and equipment, Dr. Ogdie will build a strong foundation for career in patient-oriented clinical and translational investigation.

Public Health Relevance

Psoriatic arthritis is common among patients with psoriasis and contributes to decreased quality of life and disability. This research will aid clinicians in identifying psoriatic arthritis at an earlier point in the disease course. Furthermore, the results will provide a foundation for studies investigating the pathophysiology of psoriatic arthritis development and the impact of early treatment initiation on disease outcomes.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Mentored Patient-Oriented Research Career Development Award (K23)
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Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
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Witter, James
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University of Pennsylvania
Internal Medicine/Medicine
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United States
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Manasson, Julia; Shen, Nan; Garcia Ferrer, Helga R et al. (2018) Gut Microbiota Perturbations in Reactive Arthritis and Postinfectious Spondyloarthritis. Arthritis Rheumatol 70:242-254
Ogdie, Alexis; Sparks, Jeffrey A; Angeles-Han, Sheila T et al. (2018) Barriers and Facilitators of Mentoring for Trainees and Early Career Investigators in Rheumatology Research: Current State, Identification of Needs, and Road Map to an Inter-Institutional Adult Rheumatology Mentoring Program. Arthritis Care Res (Hoboken) 70:445-453
Leung, Ying Ying; Ogdie, Alexis; Orbai, Ana-Maria et al. (2018) Classification and Outcome Measures for Psoriatic Arthritis. Front Med (Lausanne) 5:246
Takeshita, Junko; Shin, Daniel B; Ogdie, Alexis et al. (2018) Risk of Serious Infection, Opportunistic Infection, and Herpes Zoster among Patients with Psoriasis in the United Kingdom. J Invest Dermatol 138:1726-1735
Garcia Ferrer, Helga Raquel; Azan, Alexander; Iraheta, Isa et al. (2018) Potential risk factors for reactive arthritis and persistence of symptoms at 2 years: a case-control study with longitudinal follow-up. Clin Rheumatol 37:415-422
Ogdie, Alexis; Grewal, Sungat K; Noe, Megan H et al. (2018) Risk of Incident Liver Disease in Patients with Psoriasis, Psoriatic Arthritis, and Rheumatoid Arthritis: A Population-Based Study. J Invest Dermatol 138:760-767
Ogdie, Alexis; Kay McGill, Neilia; Shin, Daniel B et al. (2018) Risk of venous thromboembolism in patients with psoriatic arthritis, psoriasis and rheumatoid arthritis: a general population-based cohort study. Eur Heart J 39:3608-3614
Orbai, Ana-Maria; de Wit, Maarten; Mease, Philip J et al. (2017) Updating the Psoriatic Arthritis (PsA) Core Domain Set: A Report from the PsA Workshop at OMERACT 2016. J Rheumatol 44:1522-1528
Orbai, Ana-Maria; de Wit, Maarten; Mease, Philip et al. (2017) International patient and physician consensus on a psoriatic arthritis core outcome set for clinical trials. Ann Rheum Dis 76:673-680
Noe, M H; Grewal, S K; Shin, D B et al. (2017) Increased prevalence of HCV and hepatic decompensation in adults with psoriasis: a population-based study in the United Kingdom. J Eur Acad Dermatol Venereol 31:1674-1680

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