Goal: This proposal requests support for a Mentored Clinical Scientist Award (K23) for Dr. David Rabago to develop research expertise in the empirical assessment of physical complementary and alternative medicine (CAM) therapies. Background: Prolotherapy (PrT) is a popular, growing, unregulated CAM therapy for chronic musculoskeletal pain in which an irritant solution is injected into painful ligaments and adjacent joint spaces. No methodologically rigorous clinical or basic science trials exist demonstrating the efficacy or limitations of PrT. Knee osteoarthritis (OA) is a common condition with high patient and societal burden; there is no cure, and patients are often refractory to care. Qualifications: Dr. Rabago has been the principle investigator (PI) on one RCT evaluating a CAM therapy, and is completing his National Research Service Award clinical research fellowship at the University of Wisconsin (UW) Department of Family Medicine (DFM). Environment: The DFM and UW Medical School are committed to Dr. Rabago's development as an independent clinician-scientist, as reflected in strong letters of support from the DFM chair, mentors, and collaborators. The UW is an ideal environment for the proposed work because it provides access to experts in the basic science of musculoskeletal injury, RCT methodology, PrT, CAM and Integrative Medicine. The UW also houses programs in Rehabilitation Medicine and Sports Medicine from which to recruit subjects. Training: Through coursework, seminars, and individual and group mentoring, Dr. Rabago will acquire advanced knowledge and skills in statistics, study design, research ethics, management/leadership, scientific writing, basic science animal-model experimentation and Integrative Medicine practice. Research: During this training grant, Dr. Rabago will be the PI on an RCT assessing the efficacy of PrT for OA knee pain. He will also be the co-PI on a series of animal model experiments to assess the healing response after PrT. Significance: If received, this K23 award will facilitate 1) Dr. Rabago's training to become a researcher able to independently assess CAM therapies and 2) the assessment of PrT, a significant CAM therapy for knee OA.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23AT001879-04
Application #
7209020
Study Section
Special Emphasis Panel (ZAT1-CP (08))
Program Officer
Khalsa, Partap Singh
Project Start
2004-03-01
Project End
2009-02-28
Budget Start
2007-03-01
Budget End
2008-02-29
Support Year
4
Fiscal Year
2007
Total Cost
$119,383
Indirect Cost
Name
University of Wisconsin Madison
Department
Family Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Rabago, David; Patterson, Jeffrey J; Mundt, Marlon et al. (2014) Dextrose and morrhuate sodium injections (prolotherapy) for knee osteoarthritis: a prospective open-label trial. J Altern Complement Med 20:383-91
Rabago, David; Lee, Ken S; Ryan, Michael et al. (2013) Hypertonic dextrose and morrhuate sodium injections (prolotherapy) for lateral epicondylosis (tennis elbow): results of a single-blind, pilot-level, randomized controlled trial. Am J Phys Med Rehabil 92:587-96
Rabago, David; Patterson, Jeffrey J; Mundt, Marlon et al. (2013) Dextrose prolotherapy for knee osteoarthritis: a randomized controlled trial. Ann Fam Med 11:229-37
Rabago, David; Kijowski, Richard; Woods, Michael et al. (2013) Association between disease-specific quality of life and magnetic resonance imaging outcomes in a clinical trial of prolotherapy for knee osteoarthritis. Arch Phys Med Rehabil 94:2075-82
Rabago, David; Zgierska, Aleksandra; Fortney, Luke et al. (2012) Hypertonic dextrose injections (prolotherapy) for knee osteoarthritis: results of a single-arm uncontrolled study with 1-year follow-up. J Altern Complement Med 18:408-14
Rabago, David; Slattengren, Andrew; Zgierska, Aleksandra (2010) Prolotherapy in primary care practice. Prim Care 37:65-80
Rabago, David; Zgierska, Aleksandra; Peppard, Paul et al. (2009) The prescribing patterns of Wisconsin family physicians surrounding saline nasal irrigation for upper respiratory conditions. WMJ 108:145-50
Grote, Walter; Delucia, Rosa; Waxman, Robert et al. (2009) Repair of a complete anterior cruciate tear using prolotherapy: a case report. Int Musculoskelet Med 31:159-165
Rabago, David; Zgierska, Aleksandra (2009) Saline nasal irrigation for upper respiratory conditions. Am Fam Physician 80:1117-9
Rabago, D; Best, T M; Zgierska, A E et al. (2009) A systematic review of four injection therapies for lateral epicondylosis: prolotherapy, polidocanol, whole blood and platelet-rich plasma. Br J Sports Med 43:471-81

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