? This application is a request for a Mentored Patient-Oriented Research Career Development Award (K23) to prepare Dr. Sandra Springer to become an independent investigator. She will accomplish this goal through directed coursework, mentoring from accomplished researchers, involvement with three focused research projects and submission of scholarly manuscripts. Specifically, she will receive training in the design and implementation of interventions for adherence to antiretroviral therapy and drug treatment for opiate-addicted HIV+ individuals being released from the correctional setting. Her research has demonstrated that HIV+ prisoners with opiate dependence improve their CD4 count and viral load while incarcerated. This benefit, however, is lost as these individuals relapse to drug use, fail to adhere to antiretroviral therapy and result in poor health outcomes. Dr. Springer has also assisted with development of community-based adherence interventions for HIV+ drug users. During her career development, she will gain training and experience to connect released HIV+ prisoners to effective interventions. Dr. Springer will sequentially conduct three projects during her career development award. The first include secondary data analyses of factors that effect adherence to antiretroviral therapy among HIV+ drug users in a randomized controlled trial of directly administered antiretroviral therapy (DAART). The second project will evaluate the feasibility of linking HIV+ drug users to a methadone maintenance program and providing DAART within that setting. The third project will first link HIV+ prisoners to buprenorphine treatment upon release from prison, followed by a second feasibility study of linking them to buprenorphine plus DAART. The career development plan is a carefully staged approach to provide Dr. Springer with the skills and data necessary to develop an R01 and become an independent investigator by the end of the award. Her work will contribute greatly to the interface between HIV and substance abuse treatment where rigorously evaluated interventions are needed. ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23DA019381-03
Application #
7256508
Study Section
Special Emphasis Panel (ZDA1-MXS-M (07))
Program Officer
Grossman, Debra
Project Start
2005-09-16
Project End
2010-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
3
Fiscal Year
2007
Total Cost
$178,793
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Wickersham, Jeffrey A; Azar, Marwan M; Cannon, Christopher M et al. (2015) Validation of a Brief Measure of Opioid Dependence: The Rapid Opioid Dependence Screen (RODS). J Correct Health Care 21:12-26
Di Paola, Angela; Altice, Frederick L; Powell, Mary Lindsay et al. (2014) A comparison of psychiatric diagnoses among HIV-infected prisoners receiving combination antiretroviral therapy and transitioning to the community. Health Justice 2:
Chen, Nadine E; Meyer, Jaimie P; Avery, Ann K et al. (2013) Adherence to HIV treatment and care among previously homeless jail detainees. AIDS Behav 17:2654-66
Meyer, Jaimie P; Wickersham, Jeffrey A; Fu, Jeannia J et al. (2013) Partner violence and health among HIV-infected jail detainees. Int J Prison Health 9:124-41
Springer, Sandra A; Qiu, Jingjun; Saber-Tehrani, Ali Shabahang et al. (2012) Retention on buprenorphine is associated with high levels of maximal viral suppression among HIV-infected opioid dependent released prisoners. PLoS One 7:e38335
Springer, Sandra A (2012) High rates of depressive symptomatology among injecting drug users in Saskatoon, Canada. Evid Based Ment Health 15:9
Springer, Sandra A; Azar, Marwan M; Altice, Frederick L (2011) HIV, alcohol dependence, and the criminal justice system: a review and call for evidence-based treatment for released prisoners. Am J Drug Alcohol Abuse 37:12-21
Springer, Sandra A; Spaulding, Anne C; Meyer, Jaimie P et al. (2011) Public health implications for adequate transitional care for HIV-infected prisoners: five essential components. Clin Infect Dis 53:469-79
Meyer, Jaimie P; Springer, Sandra A; Altice, Frederick L (2011) Substance abuse, violence, and HIV in women: a literature review of the syndemic. J Womens Health (Larchmt) 20:991-1006
Granich, Reuben; Gupta, Somya; Suthar, Amitabh B et al. (2011) Antiretroviral therapy in prevention of HIV and TB: update on current research efforts. Curr HIV Res 9:446-69

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