The overarching goal of this Mentored Patient-Oriented Research Career Development Award (K23) is to provide Dr. Amanda Gilmore with the training and research activities needed to become an independent investigator. Her program of research will focus on the development, testing, and dissemination of innovative, technology-based prevention focused on adolescent substance use, sexual assault (SA), and sexual risk behaviors (SRBs) in primary care settings. Substance use, sexual assault, and sexual risk behaviors are common among adolescents. They occur concurrently and are interrelated, making integrated prevention concerning these health risk behaviors imperative. Preventative visits in pediatric primary care settings are an ideal location to implement brief, integrated prevention due to their potential for wide reach. This proposal includes training activities to ensure that Dr. Gilmore achieves the following five new career goals: 1) Receive training in integrated prevention for adolescents to become a prevention researcher focused on preventing substance use, SA, and SRBs; 2) Receive training in implementing prevention-based clinical trials in primary care settings using screening, brief intervention, and referral to treatment (SBIRT) models; 3) Enhance statistical training in clinical trials and longitudinal analyses; 4) Enhance training in the use of innovative technologies as a mode of delivering prevention programs; 5) Increase manuscript writing, grant writing, and grant management skills; and 6) Enhance understanding of research ethics. The mentorship team includes expert psychologists and pediatricians in the following areas of research: integrated prevention of adolescent risk behavior (Danielson), substance use SBIRT in pediatrics (Levy), substance use prevention among sexual assault victims (Resnick), technology-based prevention programs for adolescents (Ruggiero), research within community pediatric practice research networks (Wallis), longitudinal data analyses from clinical trials (Ramakrishnan) and interventions for sexual minorities (Kaysen). Dr. Gilmore will apply the skills acquired during the training activities to a research project focused on the adaptation and integration of evidence-based prevention programs targeting adolescent substance use, sexual assault, and sexual risk behaviors to a tablet- based prevention program for primary care. The research project includes focus groups and expert input in the adaptation/integration phase, usability tests with both adolescents and physicians within community pediatric clinics, and a feasibility study within community pediatric clinics. The feasibility study will establish feasibility of conducting a larger randomized controlled trial testing the efficacy of the newly integrated and adapted prevention program. Preliminary efficacy of the prevention program will be examined. However, determining feasibility is the primary goal. The proposed training and research activities will prepare Dr. Gilmore for an independent research career focused on the development, testing, and dissemination of prevention focused on substance use, sexual assault, and sexual risk among adolescents in primary care settings.

Public Health Relevance

Adolescent substance use, sexual assault, and sexual risk behaviors pose a great public health concern, and subsequently there is also a great need to prevent these behaviors and experiences. This project involves the adaptation and integration of evidence-based prevention content aimed at preventing and reducing substance use, sexual assault, and sexual risk behaviors. This project uses innovative technology within primary care visits to conduct a feasibility trial of an integrated prevention program.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Mentored Patient-Oriented Research Career Development Award (K23)
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Study Section
Interventions to Prevent and Treat Addictions Study Section (IPTA)
Program Officer
Lloyd, Jacqueline
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Medical University of South Carolina
Schools of Medicine
United States
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Tomko, Rachel L; Gilmore, Amanda K; Gray, Kevin M (2018) The role of depressive symptoms in treatment of adolescent cannabis use disorder with N-Acetylcysteine. Addict Behav 85:26-30
Gilmore, Amanda K; Jones, Jennifer L; Moreland, Angela D et al. (2018) Gender moderates the association between distress tolerance and alcohol use among individuals with opioid use disorder. Drug Alcohol Depend 190:9-12
Tomko, Rachel L; Jones, Jennifer L; Gilmore, Amanda K et al. (2018) N-acetylcysteine: A potential treatment for substance use disorders. Curr Psychiatr 17:30-36, 41-42, 55
Dir, Allyson L; Andrews 3rd, Arthur R; Wilson, Sarah M et al. (2018) The Role of Sex-Related Alcohol Expectancies in Alcohol-Involved Consensual and Nonconsensual Sex Among Women of Asian/Pacific Islander and Women of European Race/Ethnicity. J Sex Res 55:850-862
Gilmore, Amanda K; Bountress, Kaitlin E; Selmanoff, Mollie et al. (2018) Reducing Heavy Episodic Drinking, Incapacitation, and Alcohol-Induced Blackouts: Secondary Outcomes of a Web-Based Combined Alcohol Use and Sexual Assault Risk Reduction Intervention. Violence Against Women 24:1299-1313
Jaffe, Anna E; Bountress, Kaitlin E; Metzger, Isha W et al. (2018) Student engagement and comfort during a web-based personalized feedback intervention for alcohol and sexual assault. Addict Behav 82:23-27
Neilson, Elizabeth C; Bird, Elizabeth R; Metzger, Isha W et al. (2018) Understanding sexual assault risk perception in college: Associations among sexual assault history, drinking to cope, and alcohol use. Addict Behav 78:178-186
Gilmore, Amanda K; Price, Matthew; Bountress, Kaitlin E et al. (2018) A Longitudinal Examination of Interpersonal Violence Exposure, Concern for Loved Ones During a Disaster, and Web-Based Intervention Effects on Posttraumatic Stress Disorder Among Adolescent Victims of the Spring 2011 Tornadoes. J Interpers Violence :886260518791236
Resnick, Heidi; Zuromski, Kelly L; Galea, Sandro et al. (2017) Prior Interpersonal Violence Exposure and Experiences During and After a Disaster as Predictors of Posttraumatic Stress Disorder and Depression Among Adolescent Victims of the Spring 2011 Tornadoes. J Interpers Violence :886260517719540
Gilmore, Amanda K; Ward-Ciesielski, Erin F (2017) Perceived risks and use of psychotherapy via telemedicine for patients at risk for suicide. J Telemed Telecare :1357633X17735559

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