Abstract

The proposed study utilizes the investigator's experience in speech-language pathology and cognitive neuropsychology as well as her training in clinical neurology to identify brain- behavior relationships in hyperacute stroke (within 24 hours of onset), that is, before the opportunity for brain reorganization. The investigation will focus on the characterization and localization of naming disorders and hemispatial neglect. Cognitive testing in the hyperacute period, at 3 days and at 3 months will evaluate the mental representations and processes underlying naming and spatial attention. Areas of hypometabolism, hypoperfusion, and actual infarct associated with specific impairments in these cognitive domains will be identified with magnetic resonance imaging techniques of Perfusion Imaging (MRPI) and Diffusion Weighted Imaging (DWI) and with follow-up conventional MRI. The correlations between acute functional impairments of specific cognitive representations and physiologic or structural lesions will be used to predict the size and site of infarcted or hypoperfused neural tissue from cognitive impairments in hyperacute stroke, and will thus be useful in treatment decisions and prognosis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
1K23DC000174-01
Application #
2899089
Study Section
Communication Disorders Review Committee (CDRC)
Program Officer
Marler, John R
Project Start
1999-07-01
Project End
2002-06-30
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Neurology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Hillis, A E; Wityk, R J; Beauchamp, N J et al. (2004) Perfusion-weighted MRI as a marker of response to treatment in acute and subacute stroke. Neuroradiology 46:31-9
Hillis, A E; Wityk, R J; Barker, P B et al. (2002) Subcortical aphasia and neglect in acute stroke: the role of cortical hypoperfusion. Brain 125:1094-104
Hillis, A E; Kane, A; Tuffiash, E et al. (2001) Reperfusion of specific brain regions by raising blood pressure restores selective language functions in subacute stroke. Brain Lang 79:495-510
Hillis, A E; Wityk, R J; Tuffiash, E et al. (2001) Hypoperfusion of Wernicke's area predicts severity of semantic deficit in acute stroke. Ann Neurol 50:561-6
Hillis, A E; Barker, P B; Beauchamp, N J et al. (2001) Restoring blood pressure reperfused Wernicke's area and improved language. Neurology 56:670-2
Hillis, A E; Barker, P B; Beauchamp, N J et al. (2000) MR perfusion imaging reveals regions of hypoperfusion associated with aphasia and neglect. Neurology 55:782-8