Poor sleep and fatigue are commonly encountered in the practice of nephrology. In the general population, sleep studies using polysomnography show a substantial prevalence of sleep disordered breathing and other causes of sleep fragmentation in healthy adults that clearly contribute to sleepiness and fatigue, hypertension and cardiovascular disease. Potentially, such disorder could contribute to the very high rates of morbidity and mortality in the chronic kidney disease population. The general hypothesis for the proposed research program is that kidney failure is related to sleep disorders and these sleep disorders impact on daytime functioning. The Principal Investigator has designed a rigorous training program that will provide him with the necessary research skills, hands-on mentoring experiences, and content area expertise to develop into an independent investigator in the field of sleep and daytime functioning in chronic kidney disease. He will take courses designed to provide him the statistical, study design, and measurement methodology to carry out original research. His sponsors have extensive experience in clinical epidemiology, dialysis outcomes research, sleep disorders epidemiology and functioning outcomes methodology and are committed to his career development. The few preliminary studies using polysomnography suggest that sleep disorders may affect the majority in dialysis patients. The proposed study is designed to evaluate the full spectrum of both objectively assessed and self-reported sleep disorders and evaluate daytime functioning before and after kidney transplantation.
The Specific Aims are 1) To characterize sleep and daytime functioning in persons with advanced kidney disease and on hemodialysis 2) To characterize changes in sleep and daytime functioning in persons after kidney transplantation. Statistical power demonstrates that the proposed study has an adequate sample size to assess each aim and a pilot project has demonstrated the feasibility of recruiting patients with chronic kidney disease for sleep and daytime functioning assessments. The team of experienced mentors and consulting scientists will monitor his progress in completing his project and his career development. The proposed training program and research projects will serve as a foundation for future projects to improve the sleep and daytime functioning in persons with chronic kidney disease.
| Jhamb, Manisha; Abdel-Kader, Khaled; Yabes, Jonathan et al. (2018) Comparison of fatigue, pain and depression in patients with advanced kidney disease and cancer - symptom burden and clusters. J Pain Symptom Manage : |
| Roumelioti, Maria-Eleni; Argyropoulos, Christos; Pankratz, Vernon Shane et al. (2016) Objective and subjective sleep disorders in automated peritoneal dialysis. Can J Kidney Health Dis 3:6 |
| Abdel-Kader, Khaled; Jhamb, Manisha; Mandich, Lee Anne et al. (2014) Ecological momentary assessment of fatigue, sleepiness, and exhaustion in ESKD. BMC Nephrol 15:29 |
| Ramer, Sarah; Germain, Anne; Dohar, Sheena et al. (2012) Event-related distress in kidney disease patients. Nephrol Dial Transplant 27:299-303 |
| Kang, Ea Wha; Abdel-Kader, Khaled; Yabes, Jonathan et al. (2012) Association of sleep-disordered breathing with cognitive dysfunction in CKD stages 4-5. Am J Kidney Dis 60:949-58 |
| Roumelioti, Maria-Eleni; Buysse, Daniel J; Sanders, Mark H et al. (2011) Sleep-disordered breathing and excessive daytime sleepiness in chronic kidney disease and hemodialysis. Clin J Am Soc Nephrol 6:986-94 |
| Younas, Nizar; Wu, Christine M; Shapiro, Ron et al. (2010) HMG-CoA reductase inhibitors in kidney transplant recipients receiving tacrolimus: statins not associated with improved patient or graft survival. BMC Nephrol 11:5 |
| Abdel-Kader, Khaled; Dew, Mary Amanda; Bhatnagar, Mamta et al. (2010) Numeracy skills in CKD: correlates and outcomes. Clin J Am Soc Nephrol 5:1566-73 |
| Soni, Ritu K; Porter, Anna C; Lash, James P et al. (2010) Health-related quality of life in hypertension, chronic kidney disease, and coexistent chronic health conditions. Adv Chronic Kidney Dis 17:e17-26 |
| Soni, Ritu K; Weisbord, Steven D; Unruh, Mark L (2010) Health-related quality of life outcomes in chronic kidney disease. Curr Opin Nephrol Hypertens 19:153-9 |
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