? Wanda K. Nicholson, MD, MPH is seeking this K23 award to study the role of inflammatory markers as predictors of gestational diabetes mellitus (GDM) and incident Type 2 diabetes mellitus (Type 2 DM), to complete advanced training in the conduct of longitudinal studies, and to transition to an independent career in clinical research. Dr. Nicholson is an Assistant Professor in the Department of Gynecology and Obstetrics at Johns Hopkins and has fellowship training in clinical research and an early track record of peer reviewed clinical research. Parity has been previously linked to Type 2 DM; however, the underlying mechanism for this association is unclear. Recently, markers of inflammation (e.g. C-reactive protein) have emerged as independent predictors of Type 2 DM. No studies have examined whether the association of parity with Type 2 DM is mediated by the presence of inflammation. Moreover, it is unclear whether inflammatory markers are also predictors of GDM. She proposes to determine the effect of parity and inflammatory markers on prevalent and incident cases of Type 2 DM through cross-sectional and case-cohort analyses of the NHANES III and ARIC data, respectively. In addition, a prospective case-cohort study will assess inflammatory markers as risk predictors of GDM. This proposal will provide an in-depth examination of the role of parity and inflammatory markers in the pathogenesis of GDM and Type 2 DM. During this award, Dr. Nicholson will gain new skills and knowledge in the research methods for prospective study design, multivariate assessment of risk factors and longitudinal data analysis. The combination of observational research, primary data collection and advanced educational training will provide the basis for further prospective studies integrating the relation of parity and inflammation to GDM and Type 2 DM. This award will give Dr. Nicholson the dedicated time and experience she needs to develop into an independent clinical investigator ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
1K23DK067944-01
Application #
6808386
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Hyde, James F
Project Start
2004-09-15
Project End
2009-08-31
Budget Start
2004-09-15
Budget End
2005-08-31
Support Year
1
Fiscal Year
2004
Total Cost
$134,082
Indirect Cost
Name
Johns Hopkins University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Nicholson, Wanda; Wang, Nae Yuh; Baptiste-Roberts, Kesha et al. (2013) Association between adiponectin and tumor necrosis factor-alpha levels at eight to fourteen weeks gestation and maternal glucose tolerance: the Parity, Inflammation, and Diabetes Study. J Womens Health (Larchmt) 22:259-66
Baptiste-Roberts, Kesha; Nicholson, Wanda K; Wang, Nae-Yuh et al. (2012) Gestational diabetes and subsequent growth patterns of offspring: the National Collaborative Perinatal Project. Matern Child Health J 16:125-32
Baptiste-Roberts, Kesha; Ghosh, Payal; Nicholson, Wanda K (2011) Pregravid physical activity, dietary intake, and glucose intolerance during pregnancy. J Womens Health (Larchmt) 20:1847-51
Nicholson, W K; Witter, F; Powe, N R (2009) Effect of hospital setting and volume on clinical outcomes in women with gestational and type 2 diabetes mellitus. J Womens Health (Larchmt) 18:1567-76
Baptiste-Roberts, Kesha; Salafia, Carolyn M; Nicholson, Wanda K et al. (2009) Gross placental measures and childhood growth. J Matern Fetal Neonatal Med 22:13-23
Setse, Rosanna; Grogan, Ruby; Pham, Luu et al. (2009) Longitudinal study of depressive symptoms and health-related quality of life during pregnancy and after delivery: the Health Status in Pregnancy (HIP) study. Matern Child Health J 13:577-87
Nicholson, Wanda K; Asao, Keiko; Brancati, Frederick et al. (2006) Parity and risk of type 2 diabetes: the Atherosclerosis Risk in Communities Study. Diabetes Care 29:2349-54
Nicholson, Wanda K; Setse, Rosanna; Hill-Briggs, Felicia et al. (2006) Depressive symptoms and health-related quality of life in early pregnancy. Obstet Gynecol 107:798-806
Nicholson, Wanda K; Fox, Harold E; Cooper, Lisa A et al. (2006) Maternal race, procedures, and infant birth weight in type 2 and gestational diabetes. Obstet Gynecol 108:626-34
Nicholson, Wanda K; Fleisher, Lee A; Fox, Harold E et al. (2005) Screening for gestational diabetes mellitus: a decision and cost-effectiveness analysis of four screening strategies. Diabetes Care 28:1482-4