This application is for a """"""""Mentored Patient-Oriented Research Career Development Award"""""""" (K23). The candidate, Marney A. White, Ph.D., has a programmatic interest in disordered eating and obesity. Dr.
White aims - as a junior faculty member at Yale - to acquire necessary skills to develop into an independent clinical-researcher in the field of eating and weight problems. The training and research plan enlists the mentorship and collaboration of Carlos M. Grilo, Ph.D., Professor of Psychiatry and Director of the Eating Disorders Research Program, and Stephanie S. O'Malley, Ph.D., Professor of Psychiatry and Director of the Division of Substance Abuse Research. The mentors - along with nationally recognized consultants - will assist Dr. White in integrating and maximizing the training and research plans. Dr. White's specific training development goals proposed for the K23 are to: 1) Complete advanced training in biostatistics and epidemiology, and 2) Receive training and experience in conducting clinical trials. The research plan for this application consists of four interrelated studies designed to: 1) Employ taxometric and Grade of Membership analyses to test the dimensional versus categorical nature and diagnostic features of binge eating disorder (BED) and related diagnostic constructs, 2) Identify patient factors influencing treatment outcome for BED, 3) Investigate common mechanisms of cravings in binge eating and cigarette smoking, and 4) Conduct a placebo-controlled trial for bupropion in the treatment of BED. Together, these studies will inform the development of a larger-scale treatment outcome study of the efficacy of pharmacological agents in the treatment of BED. The proposed research has potential to inform our understanding of the nature of disordered eating and to enhance our understanding of the longer term effects of treatments. Together, the training and research plan will prepare the candidate to meet intermediate-term career goals of securing funding as an independent investigator to conduct large-scale clinical trials for disordered eating and obesity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23DK071646-03
Application #
7271889
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Podskalny, Judith M,
Project Start
2005-08-01
Project End
2010-07-31
Budget Start
2007-08-01
Budget End
2008-07-31
Support Year
3
Fiscal Year
2007
Total Cost
$135,054
Indirect Cost
Name
Yale University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
White, Marney A; Ivezaj, Valentina; Grilo, Carlos M (2017) Evaluation of a web-based cognitive behavioral smoking cessation treatment for overweight/obese smokers. J Health Psychol :1359105317701560
White, Marney A; Kalarchian, Melissa A; Levine, Michele D et al. (2015) Prognostic Significance of Depressive Symptoms on Weight Loss and Psychosocial Outcomes Following Gastric Bypass Surgery: A Prospective 24-Month Follow-Up Study. Obes Surg 25:1909-16
Boswell, Rebecca G; White, Marney A (2015) Gender differences in weight bias internalisation and eating pathology in overweight individuals. Adv Eat Disord 3:259-268
Joyner, Michelle A; Gearhardt, Ashley N; White, Marney A (2015) Food craving as a mediator between addictive-like eating and problematic eating outcomes. Eat Behav 19:98-101
Schvey, Natasha A; White, Marney A (2015) The internalization of weight bias is associated with severe eating pathology among lean individuals. Eat Behav 17:1-5
Gearhardt, Ashley N; Boswell, Rebecca G; White, Marney A (2014) The association of ""food addiction"" with disordered eating and body mass index. Eat Behav 15:427-33
Roberto, Christina A; Haynos, Ann F; Schwartz, Marlene B et al. (2013) Calorie estimation accuracy and menu labeling perceptions among individuals with and without binge eating and/or purging disorders. Eat Weight Disord 18:255-61
Bragg, M A; White, M A (2013) Examining the Relationship Between Soda Consumption and Eating Disorder Pathology. Adv Eat Disord 1:
Yau, Yvonne H C; Potenza, Marc N; White, Marney A (2013) Problematic Internet Use, Mental Health and Impulse Control in an Online Survey of Adults. J Behav Addict 2:72
White, Marney A; Grilo, Carlos M (2013) Bupropion for overweight women with binge-eating disorder: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry 74:400-6

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