The candidate is a nephrologist starting a staff position at the Mayo Clinic on July 1st, 2006. During the past 4 years as a nephrology trainee, the candidate obtained a Master's degree in Clinical Research, first-authored 10 peer-reviewed articles, and received institutional (T32) and individual (F32) National Research Awards. His expertise in the epidemiology of chronic kidney disease and in kidney function methods has gained national attention. He was a grant reviewer for the Centers for Disease Control and Prevention and will moderate a symposium at the American Society of Nephrology Renal Week (2006). ? The environment will consist of Mayo Clinic - Rochester, where he will have a joint appointment in Nephrology and Epidemiology. His sponsor, Stephen Turner, M.D., Professor of Medicine, will provide him with access to data and train him to be an independent investigator. His mentorship team will also include two Professors of Epidemiology, an Associate Professor of Biostatistics, and the Co-director of the Renal Function Laboratory where 5500 'gold-standard' kidney function measurements are performed annually. ? The project will compare kidney function measurements between a gold standard method (iothalamate clearance) and more convenient, but potentially less accurate methods, used in clinical practice and in most studies (serum creatinine, cystatin C, estimating equations, and creatinine clearance). The unique feature of this project will be to compare these kidney function methods in community-based samples (mentor's cohort and candidate's cohort). The effect of the kidney function measurement method on coronary artery calcification and risk factor associations with chronic kidney disease will be determined. ? Relevence: In the United States, 8 million adults have moderate-to-severe reductions in kidney function and are at risk for costly morbid interventions (dialysis or transplantation) and cardiovascular disease. Validation of kidney function methods is needed to identify chronic kidney disease at an earlier stage, characterize its risk factors, and develop new treatment strategies. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
1K23DK078229-01
Application #
7250354
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rankin, Tracy L
Project Start
2007-09-01
Project End
2012-08-31
Budget Start
2007-09-01
Budget End
2008-08-31
Support Year
1
Fiscal Year
2007
Total Cost
$137,707
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Hickson, LaTonya J; Rule, Andrew D; Butler Jr, Kenneth R et al. (2015) Troponin T as a Predictor of End-Stage Renal Disease and All-Cause Death in African Americans and Whites From Hypertensive Families. Mayo Clin Proc 90:1482-91
Rule, Andrew D; Bailey, Kent R; Lieske, John C et al. (2013) Estimating the glomerular filtration rate from serum creatinine is better than from cystatin C for evaluating risk factors associated with chronic kidney disease. Kidney Int 83:1169-76
Dwyer, Moira E; Krambeck, Amy E; Bergstralh, Eric J et al. (2012) Temporal trends in incidence of kidney stones among children: a 25-year population based study. J Urol 188:247-52
Glassock, Richard J; Rule, Andrew D (2012) The implications of anatomical and functional changes of the aging kidney: with an emphasis on the glomeruli. Kidney Int 82:270-7
El-Zoghby, Ziad M; Lieske, John C; Foley, Robert N et al. (2012) Urolithiasis and the risk of ESRD. Clin J Am Soc Nephrol 7:1409-15
Rule, Andrew D; Sasiwimonphan, Kewalee; Lieske, John C et al. (2012) Characteristics of renal cystic and solid lesions based on contrast-enhanced computed tomography of potential kidney donors. Am J Kidney Dis 59:611-8
Foley, Robert N; Wang, Changchun; Snyder, Jon J et al. (2011) Kidney function and risk triage in adults: threshold values and hierarchical importance. Kidney Int 79:99-111
Murata, Kazunori; Baumann, Nikola A; Saenger, Amy K et al. (2011) Relative performance of the MDRD and CKD-EPI equations for estimating glomerular filtration rate among patients with varied clinical presentations. Clin J Am Soc Nephrol 6:1963-72
Krambeck, Amy E; Rule, Andrew D; Li, Xujian et al. (2011) Shock wave lithotripsy is not predictive of hypertension among community stone formers at long-term followup. J Urol 185:164-9
Lorenz, Elizabeth C; Lieske, John C; Vrtiska, Terri J et al. (2011) Clinical characteristics of potential kidney donors with asymptomatic kidney stones. Nephrol Dial Transplant 26:2695-700

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