Dr. Maitreyi Mazumdar is an Assistant in Neurology at Children's Hospital Boston and Instructor in Neurology at Harvard Medical School. The candidate's long-term goal is to develop an independent research career focusing on the role of environmental contaminants in the development of neurological Injury and disease in children. Dr. Mazumdar's interests in this field developed during her Fellowship in neurodevelopmental toxicology, when she became aware of investigations of the effects of environmental arsenic exposure on children in Bangladesh. The proposed Career Development Plan incorporates a multi-disciplinary program designed to provide an intense, closely mentored, patient-oriented research experience, associated with a comprehensively structured didactic curriculum in environmental epidemiology, exposure assessment, advanced biostatistics, and risk assessment. Under the mentorship of Dr. David Christiani, Professor of Environmental Health at the Harvard School of Public Health, the candidate will investigate the effect of prenatal and early childhood arsenic exposure on neurodevelopment of children in Bangladesh, a country with high levels of arsenic contamination in groundwater. This research will examine epidemiological associations of arsenic exposure with measures of neurological development In infants and children, including 1) head circumference, 2) hearing impairment, 3) motor dysfunction, and 4) formal neurocognitive testing. The studies will be conducted in a cohort of 600 infants who are participating in a current study of reproductive health effects of arsenic. Additional children between the ages of 12 and 24 months will also be recruited neurodevelopmental assessment. The superb clinical, research, and teaching facilities of Children's Hospital Boston, Harvard Medical School, and the Harvard School of Public Health will support Dr. Mazumdar in meeting the objectives of her career development and research plans.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Mentored Patient-Oriented Research Career Development Award (K23)
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Special Emphasis Panel (ZES1-JAB-J (K9))
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Shreffler, Carol K
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Children's Hospital Boston
United States
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Valeri, Linda; Mazumdar, Maitreyi M; Bobb, Jennifer F et al. (2017) The Joint Effect of Prenatal Exposure to Metal Mixtures on Neurodevelopmental Outcomes at 20-40 Months of Age: Evidence from Rural Bangladesh. Environ Health Perspect 125:067015
Mazumdar, Maitreyi (2017) Does arsenic increase the risk of neural tube defects among a highly exposed population? A new case-control study in Bangladesh. Birth Defects Res 109:92-98
Lee, Jane J; Kapur, Kush; Rodrigues, Ema G et al. (2017) Anthropometric measures at birth and early childhood are associated with neurodevelopmental outcomes among Bangladeshi children aged 2-3years. Sci Total Environ 607-608:475-482
Rahman, Mohammad L; Valeri, Linda; Kile, Molly L et al. (2017) Investigating causal relation between prenatal arsenic exposure and birthweight: Are smaller infants more susceptible? Environ Int 108:32-40
Kancherla, Vijaya; Ibne Hasan, Md Omar Sharif; Hamid, Rezina et al. (2017) Prenatal folic acid use associated with decreased risk of myelomeningocele: A case-control study offers further support for folic acid fortification in Bangladesh. PLoS One 12:e0188726
Wang, Zhaoxi; Claus Henn, Birgit; Wang, Chaolong et al. (2017) Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment. Environ Health 16:81
Tauheed, Jannah; Sanchez-Guerra, Marco; Lee, Jane J et al. (2017) Associations between post translational histone modifications, myelomeningocele risk, environmental arsenic exposure, and folate deficiency among participants in a case control study in Bangladesh. Epigenetics 12:484-491
Rodrigues, Ema G; Bellinger, David C; Valeri, Linda et al. (2016) Neurodevelopmental outcomes among 2- to 3-year-old children in Bangladesh with elevated blood lead and exposure to arsenic and manganese in drinking water. Environ Health 15:44
Gleason, Kelsey M; Valeri, Linda; Shankar, A H et al. (2016) Stunting is associated with blood lead concentration among Bangladeshi children aged 2-3 years. Environ Health 15:103
Kile, Molly L; Cardenas, Andres; Rodrigues, Ema et al. (2016) Estimating Effects of Arsenic Exposure During Pregnancy on Perinatal Outcomes in a Bangladeshi Cohort. Epidemiology 27:173-81

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